AMI-1 (sodium salt)

AMI-1 is a cell permeable inhibitor of PRMTs. It inhibits both yeast Type I arginine methyltransferase Hmt1p and human PRMT1 (IC50 = 3.0 and 8.8 µM, respectively). AMI-1 also effectively blocks the activity of PRMTs 3, 4, and 6 but not that of either SET (Sub39H1, Suv39H2, SET7) or non-SET (DOT1) lysine methyltransferases. The mechanism of inhibition of PRMTs by AMI-1 involves blocking peptide-substrate binding. AMI-1 also inhibits HIV-1 reverse transcriptase (IC50 = 5.0 µM).Formal Name: 7,7'-(carbonylbis(azanediyl))bis(4-oxidonaphthalene-2-sulfonate), sodium salt. Synonyms: Arginine N-Methyltransferase Inhibitor-1. Molecular Formula: C21H12N2O9S2 . 4Na. Formula Weight: 592.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Water: 10 mg/ml. SMILES: O=C(NC1=CC(C=C(S(=O)([O-])=O)C=C2[O-])=C2C=C1)NC3=CC4=C(C([O-])=CC(S(=O)([O-])=O)=C4)C=C3.[Na+].[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C21H16N2O9S2.4Na/c24-19-9-15(33(27,28)29)7-11-5-13(1-3-17(11)19)22-21(26)23-14-2-4-18-12(6-14)8-16(10-20(18)25)34(30,31)32,,,,/h1-10,24-25H,(H2,22,23,26)(H,27,28,29)(H,30,31,32),,,,/q,4*+1/p-4. InChi Key: OEJIOAHFKHHDAW-UHFFFAOYSA-J.