AGK2

AGK2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13145-1 1 mg -

6 - 10 business days*

43.00€
Cay13145-5 5 mg -

6 - 10 business days*

146.00€
Cay13145-10 10 mg -

6 - 10 business days*

226.00€
Cay13145-25 25 mg -

6 - 10 business days*

510.00€
 
Mammalian sirtuin 2 (SIRT2) is a nicotinamide adenine dinucleotide-dependent histone deacetylase... more
Product information "AGK2"
Mammalian sirtuin 2 (SIRT2) is a nicotinamide adenine dinucleotide-dependent histone deacetylase (HDAC) with roles in cell cycle progression and tumorigenesis. AGK2 is a cell-permeable, selective inhibitor of SIRT2 (IC50 = 3.5 µM) that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels. It rescues dopamine neurons from alpha-synuclein toxicity in both in vitro and in vivo Parkinson's disease models, mimicking the effect of siRNA-mediated blockade of SIRT2 expression. AGK2 may be a useful tool for studying the roles of SIRT2 in neurodegeneration and aging, as well as cell cycle progression and tumorigenesis.Formal Name: 2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide. CAS Number: 304896-28-4. Molecular Formula: C23H13Cl2N3O2. Formula Weight: 434.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml, DMSO: 1 mg/ml. lambdamax: 222, 383 nm. SMILES: O=C(/C(C#N)=C/C1=CC=C(C2=CC(Cl)=CC=C2Cl)O1)NC3=C(C=CC=N4)C4=CC=C3. InChi Code: InChI=1S/C23H13Cl2N3O2/c24-15-6-8-19(25)18(12-15)22-9-7-16(30-22)11-14(13-26)23(29)28-21-5-1-4-20-17(21)3-2-10-27-20/h1-12H,(H,28,29)/b14-11+. InChi Key: SVENPFFEMUOOGK-SDNWHVSQSA-N.
Keywords: 2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
Supplier: Cayman Chemical
Supplier-Nr: 13145

Properties

Application: SIRT2 inhibitor
MW: 434.3 D
Formula: C23H13Cl2N3O2
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 304896-28-4| Matching products
KEGG ID : K11412 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H312, H315, H319, H332
P Phrases: P261, P264, P270, P271, P280, P312, P321, P330, P301+P310, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P361+P364, P362+P364, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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