AG-494

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative, compounds that act as PTK blockers. PTK inhibitors that preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation. AG-494 is an inhibitor of epidermal growth factor receptor kinase with an IC50 value of 1 µM in HT-22 cells.Formal Name: 2E-cyano-3-(3,4-dihydroxyphenyl)-N-phenyl-2-propenamide. CAS Number: 133550-35-3. Synonyms: Tyrphostin AG-494. Molecular Formula: C16H12N2O3. Formula Weight: 280.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH7.2) (1:1): 0.5 mg/ml, DMSO: 20 mg/ml, Ethanol: 1 mg/ml. lambdamax: 370 nm. SMILES: OC1=C(O)C=C(/C=C(C#N)/C(NC2=CC=CC=C2)=O)C=C1. InChi Code: InChI=1S/C16H12N2O3/c17-10-12(8-11-6-7-14(19)15(20)9-11)16(21)18-13-4-2-1-3-5-13/h1-9,19-20H,(H,18,21)/b12-8+. InChi Key: HKHOVJYOELRGMV-XYOKQWHBSA-N.