AG-370

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which selectively inhibit PTKs of key growth factors such as epidermal growth factor (EGF) or platelet-derived growth factor (PDGF) by blocking the phosphorylation of specific tyrosine residues. AG-370 is a selective inhibitor of PDGF receptor kinase with an IC50 value of 20 µM in human bone marrow fibroblasts. It displays comparatively weak inhibition of the EGF receptor (IC50 = 820 µM).Formal Name: 3-amino-4-(1H-indol-5-ylmethylene)-2-pentenetricarbonitrile. CAS Number: 134036-53-6. Synonyms: NSC 651712. Molecular Formula: C15H9N5. Formula Weight: 259.3. Purity: >95% (cis/trans mixture). Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:6): 0.1 mg/ml. lambdamax: 260, 367 nm. SMILES: c12c(ccc(c1)/C=C(\C(=C(\C#N)C#N)N)C#N)[nH]cc2. InChi Code: InChI=1S/C15H9N5/c16-7-12(15(19)13(8-17)9-18)6-10-1-2-14-11(5-10)3-4-20-14/h1-6,20H,19H2/b12-6+. InChi Key: CMMDWEJTQUTCKG-WUXMJOGZSA-N.