AEBSF (hydrochloride)

AEBSF is a water soluble, irreversible, broad spectrum inhibitor of serine proteases, including trypsin, chymotrypsin, plasmin, thrombin, and kallikreins. AEBSF can also prevent the activation of the ROS generator, NADPH oxidase. At 10-50 µg, AEBSF can attenuate airway inflammation in a mouse model of airway allergy. AEBSF maintains stability in slightly acidic aqueous solutions and serves as a nontoxic alternative to the organophosphate inhibitors, PMSF and DFP.Formal Name: 4-(2-aminoethyl)-benzenesulfonyl fluoride, monohydrochloride. CAS Number: 30827-99-7. Synonyms: Pefabloc SC. Molecular Formula: C8H10FNO2S . HCl. Formula Weight: 239.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 25 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 224, 267, 274 nm. SMILES: NCCC1=CC=C(S(=O)(F)=O)C=C1.Cl. InChi Code: InChI=1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10,/h1-4H,5-6,10H2,1H. InChi Key: WRDABNWSWOHGMS-UHFFFAOYSA-N.