- Search results for Cay11501
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8 products were found matching "Cay11501"!
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Item number: Cay11501-25
The family of Bcl-2 proteins plays pivotal roles in either promoting or preventing apoptosis. Bcl-2 family members contain one or more of four characteristic Bcl-2 homology (BH) domains, which are crucial for function. For example, anti-apoptotic Bcl-2 family proteins prevent death signaling by heterodimerizing with...
Keywords: | 4-[4-[(4'-chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]am... |
Application: | Potent, cell-permeable BH3 domain mimetic |
CAS | 852808-04-9 |
MW: | 813.4 D |
From 38.00€
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Item number: Cay11500-1
ABT-263 is an inhibitor of the Bcl-2 family proteins Bcl-2, Bcl-xL, and Bcl-W (Kis = is = 550 and 354 nM, respectively). ABT-263 is cytotoxic in a panel of small cell lung cancer (SCLC), leukemia, and lymphoma cell lines with a mean EC50 value of 1 µM. It induces apoptosis in influenza A-infected retinal pigment...
Keywords: | A-855071, Navitoclax,... |
Application: | Potent, cell-permeable BH3 domain mimetic |
CAS | 923564-51-6 |
MW: | 974.6 D |
From 33.00€
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Item number: Cay15550-1
Mammalian Omi/HtrA2 is a serine protease localized in mitochondria with close homology to bacterial HtrA chaperones. It is released from the mitochondria in response to apoptotic stimuli whereupon it induces cell death through both a caspase-dependent manner and a mechanism that involves its protease activity. UCF...
Keywords: | dihydro-5-[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-4,6(1H,5H)-pyrimidinedione |
Application: | OMI / HTRA2 inhibitor |
CAS | 313649-08-0 |
MW: | 495.5 D |
From 48.00€
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Item number: Cay15501-1
Chlorothricin is a macrolide-type antibiotic that inhibits pyruvate carboxylases from Bacillus, Azotobacter, rat, and chicken, preventing the conversion of pyruvate to oxaloacetate (Ki or IC50 = 173, 500, 260, and 120 µM, respectively). Chlorothricin also inhibits malate dehydrogenases MDH1 (cytoplasmic) and MDH2...
Keywords: | Antibiotic K 818A,... |
Application: | Macrolide-type antibiotic, Pyruvate carboxylase inhibitor |
CAS | 34707-92-1 |
MW: | 955.5 D |
From 205.00€
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Item number: Cay15001-5
JWH 018 (Cay-10900) is a potent synthetic cannabinoid which has been identified in smoking mixtures. NNEI is an analog of JWH 018 which differs by having an amide linker inserted between the naphthalene and ketone groups. The physiological and toxicological properties of this compound are not known. This product is...
Keywords: | MN-24, N-1-naphthalenyl-1-pentyl-1H-indole-3-carboxamide |
Application: | Analytical reference standard, Synthetic cannabinoid analog (JWH 018 analog) |
CAS | 1338925-11-3 |
MW: | 356.5 D |
From 291.00€
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Item number: Cay15011-250
(±)-Ibutilide is a class III antiarrhythmic agent. It inhibits the rapidly activating delayed-rectifier potassium current (IKr) in AT-1 myocytes with an IC50 value of 20 nM. (±)-Ibutilide also enhances the late inward sodium current (INa) and increases the action potential duration in isolated guinea pig ventricular...
Keywords: | U-70226E, N-[4-[4-(ethylheptylamino)-1-hydroxybutyl]phenyl]-methanesulfonamide, 2E-butenedioate (2:1) |
Application: | Potassium channel blocker |
CAS | 122647-32-9 |
MW: | 442.6 D |
From 114.00€
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Item number: Cay11506-1
Coenzyme Q10 (CoQ10) is a quinone that is found throughout the human body in cell membranes, primarily in mitochondrial membranes, with the highest levels in the heart, lungs, liver, kidneys, spleen, pancreas, and adrenal glands. It exists in three redox states: fully oxidized (CoQ10/ubiquinone), partially reduced...
Keywords: | CoQ10, NSC 140865, Ubidecarenone, Ubiquinone Q10, Ubiquinone-10,... |
Application: | Antioxidants |
CAS | 303-98-0 |
MW: | 863.4 D |
From 48.00€
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Item number: Cay11505-1
Poly(ADP-ribose) polymerases (PARPs) have diverse roles in cellular processes, including DNA repair and apoptosis. ABT-888 is an orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5.2 and 2.9 nM, respectively). It enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including...
Keywords: | Veliparib, 2-[(2R)-2-methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide, dihydrochloride |
Application: | PARP1 / PARP2 inhibitor |
CAS | 912445-05-7 |
MW: | 317.2 D |
From 60.00€
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