- Search results for Cay11500
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9 products were found matching "Cay11500"!
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Item number: Cay11500-5
ABT-263 is an inhibitor of the Bcl-2 family proteins Bcl-2, Bcl-xL, and Bcl-W (Kis = is = 550 and 354 nM, respectively). ABT-263 is cytotoxic in a panel of small cell lung cancer (SCLC), leukemia, and lymphoma cell lines with a mean EC50 value of 1 µM. It induces apoptosis in influenza A-infected retinal pigment...
Keywords: | A-855071, Navitoclax,... |
Application: | Potent, cell-permeable BH3 domain mimetic |
CAS | 923564-51-6 |
MW: | 974.6 D |
From 33.00€
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Item number: Cay11550-25
5-Methoxy-N,N-diisopropyltryptamine (5-MeO DiPT) (Cay-11865) is a psychedelic hallucinogen which is abused worldwide. Known informally as 'foxy', this compound potently inhibits the re-uptake of dopamine, serotonin, and norepinephrine (IC50s = 65, 2.2, and 8.2 µM, respectively). DiPT is an uncommonly abused...
Keywords: | N,N-Diisopropyltryptamine, N,N-bis(1-methylethyl)-1H-indole-3-ethanamine |
Application: | Analytical reference standard, Uncommonly abused psychedelic drug related to 5-MeO DiPT |
CAS | 14780-24-6 |
MW: | 244.4 D |
From 258.00€
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Item number: Cay15550-1
Mammalian Omi/HtrA2 is a serine protease localized in mitochondria with close homology to bacterial HtrA chaperones. It is released from the mitochondria in response to apoptotic stimuli whereupon it induces cell death through both a caspase-dependent manner and a mechanism that involves its protease activity. UCF...
Keywords: | dihydro-5-[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-4,6(1H,5H)-pyrimidinedione |
Application: | OMI / HTRA2 inhibitor |
CAS | 313649-08-0 |
MW: | 495.5 D |
From 48.00€
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Item number: Cay15500-2.5
Cercosporamide is a natural antifungal phytotoxin isolated from the Cercosporidium fungus, which infects the leaves of cassava plants. Its antifungal effect results from its selective and potent inhibition of fungal PKC-like 1 kinases (Pkc1), which are central to cell wall integrity (IC50 = 25 nM for Candida Pkc1)....
Keywords: | (9aS)-8-acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-4-dibenzofurancarboxamide |
Application: | Fungal Pkc1 inhibitor |
CAS | 131436-22-1 |
MW: | 331.3 D |
From 324.00€
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Item number: Cay11504-10
AM679 is a potent synthetic cannabinoid (CB) with Ki values of 13.5 and 49.5 nM for the CB1 and CB2 receptors, respectively. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.Formal Name:...
Keywords: | (2-iodophenyl)(1-pentyl-1H-indol-3-yl)-methanone |
Application: | Analytical reference standard, Potent synthetic cannabinoid |
CAS | 335160-91-3 |
MW: | 417.3 D |
From 276.00€
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Item number: Cay11505-10
Poly(ADP-ribose) polymerases (PARPs) have diverse roles in cellular processes, including DNA repair and apoptosis. ABT-888 is an orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5.2 and 2.9 nM, respectively). It enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including...
Keywords: | Veliparib, 2-[(2R)-2-methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide, dihydrochloride |
Application: | PARP1 / PARP2 inhibitor |
CAS | 912445-05-7 |
MW: | 317.2 D |
From 60.00€
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Item number: Cay11501-10
The family of Bcl-2 proteins plays pivotal roles in either promoting or preventing apoptosis. Bcl-2 family members contain one or more of four characteristic Bcl-2 homology (BH) domains, which are crucial for function. For example, anti-apoptotic Bcl-2 family proteins prevent death signaling by heterodimerizing with...
Keywords: | 4-[4-[(4'-chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]am... |
Application: | Potent, cell-permeable BH3 domain mimetic |
CAS | 852808-04-9 |
MW: | 813.4 D |
From 38.00€
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Item number: Cay11599-100
MEK kinases are central components of diverse intracellular signaling pathways. MEK1 and MEK2 specifically act downstream of growth factor receptors and the proto-oncogenes Ras and Raf to activate ERK1 and ERK2, often leading to an increase in cell proliferation. AZD 6244 is a potent, highly selective inhibitor of...
Keywords: | ARRY-142886, CL 1,040, NSC 741O78, Selumetinib,... |
Application: | MEK1 / MEK2 inhibitor |
CAS | 606143-52-6 |
MW: | 457.7 D |
From 43.00€
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Item number: Cay11596-100
MDV 3100 is a non-steroidal androgen receptor antagonist (IC50 = 36 nM). It reduces the efficiency of nuclear translocation of the androgen receptor and impairs both its binding to DNA and the recruitment of coactivators. It is orally available and induces tumor regression in mouse models of castration-resistant...
Keywords: | Enzalutamide,... |
Application: | Androgen receptor antagonist |
CAS | 915087-33-1 |
MW: | 464.4 D |
From 40.00€
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