3 products were found matching "Cay14404"!

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A-771726
A-771726

Item number: Cay14404-25

A-771726 is an active metabolite of the prodrug leflunomide (Cay-14860) that inhibits dihydroorotate dehydrogenase (DHODH, IC50 = 0.23 µM). A-771726 inhibits the production of prostaglandin E2 (PGE2, Cay-14010) in TNF-alpha- or IL-1alpha-stimulated isolated human synoviocytes (IC50s = 7 and 3 µM, respectively). It...
Keywords: Flucyamide, HMR 1726, SU 20, Teriflunomide, 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2Z-butenamide
Application: Dihydroorotate dehydrogenase inhibitor, Tyrosine kinase inhibitor
CAS 163451-81-8
MW: 270.2 D
From 84.00€ *
Review
AK-7
AK-7

Item number: Cay14004-25

The sirtuin SIRT2 is a deacetylase which targets alpha-tubulin, histone 4, forkhead transcription factors, and several other substrates. It has roles in metabolic diseases, cancer, age-related disorders, and neurodegenerative diseases, potentially including Alzheimer's, Huntington's, and Parkinson's diseases. AK-7...
Keywords: N-(3-bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide
Application: SIRT2 Inhibitor
CAS 420831-40-9
MW: 437.4 D
From 98.00€ *
Review
Pinostilbene
Pinostilbene

Item number: Cay14044-5

Pinostilbene is a stable, monomethoxylated resveratrol derivative with enhanced bioavailability compared to resveratrol. At 0.1-10 µM pinostilbene reduces neurotoxicity in SH-SY5Y cells induced by the parkinsonian mimetic 6-hydroxydopamine and scavenges 2,2-diphenyl-1-picrylhydrazyl radicals with an IC50 value of...
Keywords: 3-[(1E)-2-(4-hydroxyphenyl)ethenyl]-5-methoxy-phenol
Application: Stable resveratrol derivative
CAS 42438-89-1
MW: 242.3 D
From 34.00€ *
Review