A-7 (hydrochloride)

Calmodulin is a calcium-dependent protein that regulates the activity of a diverse array of enzymes, ion channels, and other proteins and thus has diverse roles in cell function. A-7 is an analog of the napthalenesulfonamide W-7 (Cay-14826) that has an acyl chain length of 10 carbons, rather than six. It is a potent cell-permeable antagonist of calmodulin that inhibits Ca2+/calmodulin cyclic nucleotide phosphodiesterase more potently than W-7 (IC50 = 3.2 and 26 µM, respectively).Formal Name: N-(10-aminodecyl)-5-chloro-1-naphthalenesulfonamide, monohydrochloride. CAS Number: 79127-24-5. Molecular Formula: C20H29ClN2O2S . HCl. Formula Weight: 433.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml. lambdamax: 225, 296 nm. SMILES: O=S(C1=CC=CC2=C(Cl)C=CC=C21)(NCCCCCCCCCCN)=O.Cl. InChi Code: InChI=1S/C20H29ClN2O2S.ClH/c21-19-13-9-12-18-17(19)11-10-14-20(18)26(24,25)23-16-8-6-4-2-1-3-5-7-15-22,/h9-14,23H,1-8,15-16,22H2,1H. InChi Key: XDJCAQBTSCRBHS-UHFFFAOYSA-N.