9,12-Octadecadiynoic acid is an inhibitor of both COX and lipoxygenase. 9,12-octadecadiynoic acid inhibits ram seminal vesicle COX with a Ki of 0.6 µM. It is a more effective inhibitor of COX-1 than of 15-LO, inhibiting 95% and 68%, respectively, of these enzymatic activities when used at a concentration of 48...

Lipoxin A4 (LXA4) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of (±)15-HETE (Cay-34700) or 15-HpETE with human leukocytes. LXA4 is equipotent to leukotriene B4 (Cay-20110) in inducing superoxide generation in human neutrophils at 0.1 µM. LXA4 is associated with several...

Lipoxin B4 (LXB4) is a positional isomer of LXA4 (Cay-90410) produced by the metabolism of 15-HETE (Cay-34700) or 15(S)-HpETE (Cay-44720) by human leukocytes. At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 (LTB4, Cay-20110) and inhibits...

Lipid-derived lipoxins are produced at the site of vascular and mucosal inflammation where they down-regulate polymorphonuclear leukocyte recruitment and function. 15(R)-Lipoxin A4 (15(R)-LXA4) is derived from the aspirin-triggered formation of 15(R)-HETE (Cay-34710) from arachidonic acid (Cay-90010). 15(R)-LXA4...