8(S)-HETE

8(S)-HETE is a major lipoxygenase product in PMA-treated murine epidermis. It activates mouse keratinocyte protein kinase C with an IC50 of 100 µM. 8(S)-HETE also activates PPARalpha selectively at concentrations as low as 0.3 µM. Stereochemical assignment of the (S) enantiomer is based on comparison of chiral HPLC retention times to published results.Formal Name: 8S-hydroxy-5Z,9E,11Z,14Z-eicosatetraenoic acid. CAS Number: 98462-03-4. Synonyms: 8(S)-Hydroxyeicosatetraenoic Acid. Molecular Formula: C20H32O3. Formula Weight: 320.5. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: 0.1 M Na2CO3: 2 mg/ml, DMF: Miscible, DMSO: Miscible, Ethanol: Miscible, PBS pH 7.2: 0.8 mg/ml. lambdamax: 237 nm. SMILES: CCCCC/C=C\C\C=C\C=C/[C@@H](O)C/C=C\CCCC(=O)O. InChi Code: InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-10-13-16-19(21)17-14-11-12-15-18-20(22)23/h6-7,9-11,13-14,16,19,21H,2-5,8,12,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,14-11-,16-13+/t19-/m1/s1. InChi Key: NLUNAYAEIJYXRB-VYOQERLCSA-N.