(±)8(9)-EpETE

Eicosapentaenoic acid (EPA, Cay-90110) is converted to epoxyeicosatetraenoic acids (EpETEs) by several cytochrome P450 isoforms. The major product of this epoxygenase pathway, (±)17(18)-EpETE (Cay-50861), relaxes vascular and airway smooth muscle by activating large conductance Ca2+-activated K+ (BKCa) channels by directly interacting with BKalpha channel subunits. (±)8(9)-EpETE is an epoxygenase pathway product produced from EPA by CYP450 both in vitro and in vivo. The biological actions and physiological effects of this epoxide remain to be determined.Formal Name: (±)8,9-epoxy-5Z,11Z,14Z,17Z-eicosatetraenoic acid. CAS Number: 851378-93-3. Synonyms: (±)8,9-EEQ, (±)8,9-epoxy Eicosatetraenoic Acid. Molecular Formula: C20H30O3. Formula Weight: 318.5. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: CC/C=C\C/C=C\C/C=C\C[C@@H](O1)[C@@H]1C/C=C\CCCC(O)=O. InChi Code: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-12-15-18-19(23-18)16-13-10-11-14-17-20(21)22/h3-4,6-7,9-10,12-13,18-19H,2,5,8,11,14-17H2,1H3,(H,21,22)/b4-3-,7-6-,12-9-,13-10-/t18-,19+/m1/s1. InChi Key: YKIOHMXLFWMWKD-SROXAULOSA-N.