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Product information "8-iso-17-phenyl trinor Prostaglandin F2beta"
Bimatoprost (free acid) is a metabolically stable analog of prostaglandin F2alpha (PGF2alpha) and a potent agonist for the FP receptor. It binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2alpha. At the rat recombinant FP receptor expressed in CHO cells bimatoprost inhibits PGF2alpha binding with a Ki of 1.1 nM. The isopropyl ester of bimatoprost is slightly better than PGF2alpha isopropyl ester in reducing the intraocular pressure in the cat eye without any irritation. 8-iso-17-phenyl PGF2beta is an isomer of bimatoprost that is epimerized at the 8 and 9 positions. There are no published reports on the biological activity of 8-iso-17-phenyl PGF2beta.Formal Name: 9beta,11alpha,15S-trihydroxy-17-phenyl-(8beta)-prosta-5Z,13E-dien-1-oic acid. Synonyms: 8-iso-17-phenyl PGF2beta. Molecular Formula: C23H32O5. Formula Weight: 388.5. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: O[C@H]1[C@@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C1. InChi Code: InChI=1S/C23H32O5/c24-18(13-12-17-8-4-3-5-9-17)14-15-20-19(21(25)16-22(20)26)10-6-1-2-7-11-23(27)28/h1,3-6,8-9,14-15,18-22,24-26H,2,7,10-13,16H2,(H,27,28)/b6-1-,15-14+/t18-,19-,20+,21+,22+/m0/s1. InChi Key: YFHHIZGZVLHBQZ-YDJWCRLFSA-N.
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