Maresin 1

Maresin 1 is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids. It is produced from docosahexaenoic acid (DHA, Cay-90310, Cay-17950) in human peripheral blood mononuclear cells (PBMCs). Maresin 1 (100 nM) reduces TNF-alpha-induced increases in reactive oxygen species (ROS) in primary human vascular smooth muscle and endothelial cells. It decreases disease severity, neutrophil infiltration, and intestinal crypt damage in a mouse model of colitis induced by dextran sulfate (DSS, Cay-23250) when administered at doses of 0.3 and 1 µg/animal. Maresin 1 (0.1, 1, and 10 ng/animal) inhibits increases in inflammatory exudate polymorphonuclear (PMN) neutrophil infiltration in a mouse model of peritonitis induced by zymosan A (Cay-21175). It has been found in the synovial fluid of rheumatoid arthritis patients.Formal Name: 7R,14S-dihydroxy-4Z,8E,10E,12Z,16Z,19Z-docosahexaenoic acid. CAS Number: 1268720-28-0. Synonyms: 7(R)-MaR1, 7(R)-Maresin 1. Molecular Formula: C22H32O4. Formula Weight: 360.5. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 0.05 mg/ml. lambdamax: 271 nm. SMILES: O[C@@H](/C=C/C=C/C=C\[C@@H](O)C/C=C\C/C=C\CC)C/C=C\CCC(O)=O. InChi Code: InChI=1S/C22H32O4/c1-2-3-4-5-6-10-15-20(23)16-11-7-8-12-17-21(24)18-13-9-14-19-22(25)26/h3-4,6-13,16-17,20-21,23-24H,2,5,14-15,18-19H2,1H3,(H,25,26)/b4-3-,8-7+,10-6-,13-9-,16-11-,17-12+/t20-,21-/m0/s1. InChi Key: HLHYXXBCQOUTGK-FHCQLJOMSA-N.