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AT7519 (hydrochloride)
AT7519 (hydrochloride)

Item number: Cay16231-5

AT7519 is an ATP-competitive inhibitor of cyclin-dependent kinases (Cdks) with IC50 values of 210, 47, 100, 13, 170, and 50 = 89 nM). AT7519 demonstrates antiproliferative activity against a wide variety of human tumor cell lines (IC50s = 40-940 nM in vitro), inhibiting cell cycle progression and inducing apoptosis,...
Keywords: 4-[(2,6-dichlorobenzoyl)amino]-N-4-piperidinyl-1H-pyrazole-3-carboxamide, monohydrochloride
Application: CDK inhibitor
CAS 902135-91-5
MW: 418.7 D
From 43.00€ *
Review
BIX02188
BIX02188

Item number: Cay16238-5

BIX02188 is a potent inhibitor of MEK5 (IC50 = 4.3 nM) with reduced activity towards inhibition of ERK5 and TGFbetaR1 (IC50s = 810 and 1,800 nM, respectively). It does not inhibit the closely related kinases MEK1, MEK2, ERK2, and JNK2 (IC50s = > 6,300 nM). BIX02188 inhibits phosphorylation of ERK5 in a...
Keywords: (3Z)-3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide
Application: MEK5 inhibitor
CAS 334949-59-6
MW: 412.5 D
From 60.00€ *
Review
2'-Deoxyadenosine-5'-monophosphate (hydrate)
2'-Deoxyadenosine-5'-monophosphate (hydrate)

Item number: Cay16218-5

2'-Deoxyadenosine-5'-monophosphate is a derivative of the nucleic acid, AMP, in which the hydroxyl group on the 2' carbon of the pentose has been reduced to a hydrogen atom. It has been used in the synthesis of novel photoaffinity labels for incorporation into DNA and to study adenosine-based interactions during DNA...
Keywords: 2'-Deoxy-5'-AMP, dAMP, NSC 77680, NSC 82625, 2'-deoxy-5'-adenylic acid, hydrate
CAS 653-63-4
MW: 331.2 D
From 60.00€ *
Review