7 products were found matching "Cay81040-50"!

Diphenyleneiodonium (DPI) is an inhibitor of NADPH oxidase (NOX, EC50 = 0.1 µM in HeLa cells). It also inhibits nitric oxide synthase (NOS, IC50 = 0.05 µM in isolated mouse peritoneal macrophages). DPI (10, 50, and 100 µM) induces the production of reactive oxygen species (ROS) in, and apoptosis of, human umbilical...

TC 14012 is a peptidomimetic antagonist of chemokine (C-X-C motif) receptor 4 (CXCR4, IC50 = 2.9 nM) and CXCR7 agonist. It induces beta-arrestin recruitment in HEK293T cells expressing CXCR7 (EC50 = 350 nM). TC 14012 reduces the cytopathic effect of HIV in infected MT-4 cells (EC50 = 0.4 nM) and inhibits HIV entry...

Photoswitchable PAD inhibitor is a photoactivated protein arginine deiminase (PAD) inhibitor and a derivative of BB-Cl-amidine (Cay-17079) that contains an azobenzene photoswitch allowing optical control of PAD activity. Without photoactivation, it is a weak inhibitor of PAD2 (IC50 = >100 µM) and is less potent than...

7-Nitroindazole is a non-selective inhibitor of NOS isoforms in vitro. However, it shows good anti-nociceptive effects in vivo without affecting blood pressure via inhibition of eNOS. The IC50 values for inhibition of rat nNOS, bovine eNOS, and rat iNOS are 0.71, 0.78, and 5.8 µM, respectively.Formal Name:...

NOD1 is a member of the NACHT and leucine-rich repeat domain-containing proteins (NLR) family of innate immunity proteins. It recognizes distinct molecular patterns from bacterial ligands and activates NF-kappaB, stress kinases, and interferon response factors important for host defense and inflammation. Hereditary...

PAPA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 15 minutes and 77 minutes at 37°C and 22-25°C, respectively, (pH 7.4) to liberate 2 moles of NO per mole of parent compound.Formal Name:...

The enzyme 15-hydroxy prostaglandin dehydrogenase (15-PGDH) initiates the catabolism of PGs and related eicosanoids. SW033291 is a potent inhibitor of 15-PGDH (Ki = ~0.1 nM) that has activity in vivo. It rapidly increases the levels of PGE2 in bone marrow and other tissues in mice after intraperitoneal injection....