10 products were found matching "Cay16531"!

Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. CHIR124 is a cell-permeable, quinolone-based inhibitor of Chk1 (IC50 = 0.3 nM in vitro). It demonstrates high selectivity for Chk1 by displaying inhibitory values 2,000-fold higher against Chk2 (IC50 = 0.7 µM). In...

NOC-5 is a stable nitric oxide (NO)-amine complex that acts as a NO donor. It can release two equivalents of NO in solution under physiological conditions without a cofactor. The half-life of NOC-5 in PBS (pH 7.4) is 93 minutes at 22°C, and it remains relatively stable in alkaline solution (pH >10.0).Formal Name:...

2-Oleoyl glycerol (2-OG) is a natural monoacylglycerol with an 18:1 oleoyl group at the sn-2 position of glycerol. 2-OG, like 2-arachidonoyl glycerol (2-AG, Cay-62160), is metabolized by monoacylglycerol lipase, but, unlike 2-AG, it is not metabolized by cyclooxygenases or lipoxygenases. 2-OG is an agonist of GPR119...

Nisin A is a bacteriocin, a natural polycyclic antibacterial peptide. It is produced by the lactic acid bacterium L. lactis using uncommon amino acids, including lanthionine, and is a member of the class of antibiotics referred to as lantibiotics. Nisin A is particularly effective against Gram-positive bacteria and...

Dilauroyl-rac-glycerol is comprised of a mixture of C12:0 diglyceride racemates with acyl groups attached at either alpha, alpha- or alpha, beta-positions. It has been used for the investigation of biological and physicochemical relationships of membrane glycerides. It has also been employed as an industrial...

Mouse anti-6His IgG, unconjugated Antibody: Mouse anti-6x Histidine IgG, clone AD1.1.10 Isotype: IgG1-kappa Reactivity: Polyhisitidine tagged proteins (N- or C-terminus label) Uses: ELISA and Western blot analysis: 1:500-1:1,000, IHC: 1:250-750 dilutionFormulation: (Request formulation change), A liquid....

AB-CHMINACA (Cay-15434) is a cyclohexyl-substituted derivative of the indazole-based synthetic cannabinoid, AB-FUBINACA (Cay-14039). AB-CHMINACA metabolite M6 is a potential metabolite in which the carboxamide-linked aminocarbonyl-2-methylpropyl side chain associated with both AB-CHMINACA and AB-FUBINACA features an...

Deferasirox is an orally bioavailable synthetic, tridentate iron chelator that binds iron at a 2:1 ratio. It is selective for iron (Fe(III)) over Cu(II), Zn(II), Mg(II), and Ca(II) but does bind to Al(III). Deferasirox decreases iron levels in iron-loaded rat heart cells in vitro by 45.8 and 55.6% compared to...

Retinoic acid receptor-related orphan receptors alpha and gamma (RORalpha and RORgamma) have been demonstrated to play important roles in the regulation of metabolism, circadian rhythms, immune function, and tumorigenesis. SR 1078 is a selective agonist of RORalpha and RORgamma that stimulates ROR transcriptional...

GNF-2 is an allosteric inhibitor of Bcr-Abl (IC50 = 267 nM). It is selective for Bcr-Abl over c-Abl and a panel of 63 additional kinases at 10 µM. It inhibits proliferation of Ba/F3 cells (IC50 = 138 nM). GNF-2 (10 µM) reduces viral titers in Vero cells infected with infectious bronchitis virus (IBV), a coronavirus,...