6-Aminonicotinamide

6-Aminonicotinamide
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10009315-100 100 mg -

6 - 10 business days*

20.00€
Cay10009315-250 250 mg -

6 - 10 business days*

42.00€
Cay10009315-500 500 mg -

6 - 10 business days*

77.00€
Cay10009315-1 1 g -

6 - 10 business days*

131.00€
 
6-Aminonicotinamide (6-AN) is a well-established inhibitor of the NADP+-dependent enzyme,... more
Product information "6-Aminonicotinamide"
6-Aminonicotinamide (6-AN) is a well-established inhibitor of the NADP+-dependent enzyme, 6-phosphogluconate dehydrogenase (Ki = 0.46 µM). Through this action, 6-AN interferes with glycolysis, resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, like cisplatin, in killing cancer cells (IC50 = 0.5 mM). 6-AN also reduces cardiovascular oxidative injury following ischemia/reperfusion. In addition, 6-AN causes glial neurodegeneration.Formal Name: 6-amino-3-pyridinecarboxamide. CAS Number: 329-89-5. Synonyms: 6-AN, NSC 21206, SR 4388. Molecular Formula: C6H7N3O. Formula Weight: 137.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml, DMSO: 1 mg/ml. lambdamax: 269 nm. SMILES: Nc1ccc(cn1)C(=O)N. InChi Code: InChI=1S/C6H7N3O/c7-5-2-1-4(3-9-5)6(8)10/h1-3H,(H2,7,9)(H2,8,10). InChi Key: ZLWYEPMDOUQDBW-UHFFFAOYSA-N.
Keywords: 6-AN, NSC 21206, SR 4388, 6-amino-3-pyridinecarboxamide
Supplier: Cayman Chemical
Supplier-Nr: 10009315

Properties

Application: 6-phosphogluconate dehydrogenase inhibitor
MW: 137.1 D
Formula: C6H7N3O
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 329-89-5| Matching products
KEGG ID : K00033 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H360
P Phrases: P201, P202, P280, P308+313, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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