5-bromo-3-phenyl Salicylic Acid

The aldo-keto reductase (AKR) enzymes constitute a family of related NADPH-dependent oxidoreductases. The 1C subfamily (AKR1C) includes four human hydroxysteroid dehydrogenases (HSDs), with AKR1C1 being a 20alpha-HSD and the other three being 3alpha-HSDs. AKR1C1 metabolizes progesterone to an inactive progestin, 20alpha-hydroxy progesterone. In addition, AKR1C1 actions have been implicated in cancer and in the processing of neuroactive steroids involved in brain function. 5-bromo-3-phenyl Salicyclic acid selectively inhibits AKR1C1 (Ki = 140 nM) over AKR1C2 (K1 = 1.97 µM) and AKR1C3 (Ki = 21 µM). It does not inhibit AKR1C4 at 100 µM.Formal Name: 5-bromo-2-hydroxy-[1,1'-biphenyl]-3-carboxylic acid. CAS Number: 99514-99-5. Molecular Formula: C13H9BrO3. Formula Weight: 293.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml, DMSO: 20 mg/ml, Ethanol: 3 mg/ml. lambdamax: 220, 301 nm. SMILES: BrC1=CC(C2=CC=CC=C2)=C(O)C(C(O)=O)=C1. InChi Code: InChI=1S/C13H9BrO3/c14-9-6-10(8-4-2-1-3-5-8)12(15)11(7-9)13(16)17/h1-7,15H,(H,16,17). InChi Key: HUQWWRUNBHYQLK-UHFFFAOYSA-N.