4-1BB Ligand, human recombinant

4-1BB Ligand, human recombinant
Item number Size Datasheet Manual SDS Delivery time Quantity Price
97391.5 5 µg - -

3 - 10 business days*

94.00€
97391.20 20 µg - -

3 - 10 business days*

208.00€
97391.1 1 mg - -

3 - 10 business days*

3,952.00€
 
Human recombinant 4 1BBL produced in E.coli is a single, non-glycosylated, polypeptide chain... more
Product information "4-1BB Ligand, human recombinant"
Human recombinant 4 1BBL produced in E.coli is a single, non-glycosylated, polypeptide chain containing 184 amino acids and having a molecular mass of 19.5kDa. 4-1BBL is a transmembrane cytokine that is part of the tumor necrosis factor (TNF) ligand family. 4-1BBL is a bidirectional signal transducer that performs as a ligand for TNFRSF9, which is a costimulatory receptor molecule in T lymphocytes. TNFSF9 and its TNFRSF9 take part in the antigen presentation development and in the generation of cytotoxic T cells. 4-1BBR is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. TNFSF9 reactivates anergic T lymphocytes as well as promoting T lymphocyte proliferation. 4-1BB Ligand is needed for the optimal CD8 responses in CD8 T cells. 4-1BBL is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction. 4-1BBL is expressed by activated B cells, macrophages, dendritic cells, activated T cells, neurons and astrocytes. The interaction of 4-1BB with TNFRSF9 strongly regulates immunity and has been proposed to preferentially control T cell responses based on studies in various murin.
Keywords: CD137L, CD137-L, 4-1BBL, 4-1BB Ligand, TNFSF9, Tumor Necrosis Factor (ligand) Superfamily Member 9.
Supplier: Biomol GmbH
Supplier-Nr: 97391

Properties

Application: Cell Culture
Conjugate: No
Host: E.coli
Species reactivity: human
MW: 19500 D
Purity: >95%
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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