4 products were found matching "Cay16366"!
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(2R)-Octyl-alpha-hydroxyglutarate
Item number: Cay16366-10
alpha-Hydroxyglutaric acid (2-HG, Cay-16374) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder. Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2,...
| Keywords: | (2R)-Octyl-2-HG, 2R-hydroxy-pentanedioic acid, 1-octyl ester |
| CAS | 1391194-67-4 |
| MW: | 260.3 D |
From 73.00€
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Amphotericin B
Item number: Cay11636-500
Amphotericin B is a classic antifungal polyene macrolide that has been used in the treatment of systemic fungal infections, primarily caused by C. albicans, A. fumigatus, and parasitic L. protozoans, as well as in tissue culture to prevent fungi from contaminating cell cultures. Amphotericin B binds with ergosterol,...
| Keywords: | Abelcet(R), AmBisome(R), Ampho-Moronal(R), Amphocin(R), Amphozone(R), Fungilin(R), Fungizone(R), Halizon(R), LNS-AmB, NSC... |
| Application: | Antibiotic, Antifungal polyene macrolide |
| CAS | 1397-89-3 |
| MW: | 924.1 D |
From 53.00€
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Ku-55933
Item number: Cay16336-1
Ku-55933 is a potent ATP-competitive inhibitor of the ataxia-telangiectasia mutated (ATM) kinase (IC50 = 13 nM, Ki = 2.2 nM). Inhibition of ATM by Ku-55933 blocks radiation-induced phosphorylation of downstream cellular targets and sensitizes cells to the cytotoxic effects of both ionizing radiation and...
| Keywords: | ATM Kinase Inhibitor, 2-(4-morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one |
| Application: | Potent ATP-competitive ATM kinase inhibitor |
| CAS | 587871-26-9 |
| MW: | 395.5 D |
From 38.00€
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RP 001 (hydrochloride)
Item number: Cay16636-10
RP 001 is a potent sphingosine-1-phosphate receptor 1 (S1P1) agonist (EC50 = 9 pM). It is competitive with W146 (Cay-10009109), a selective S1P1 antagonist, and induces internalization and polyubiquitination of S1P1 in a dose-dependent manner. RP 001 induces dose-dependent lymphopenia in mice (EC50 = 0.03 mg/kg). It...
| Keywords: | N-[4-[5-[3-cyano-4-(1-methylethoxy)phenyl]-1,2,4-oxadiazol-3-yl]-2,3-dihydro-1H-inden-1-yl]-beta-alanine, monohydrochloride |
| Application: | Potent S1P1 receptor agonist |
| CAS | 1781880-34-9 |
| MW: | 468.9 D |
From 50.00€
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