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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay11138-1 | 1 g | - |
6 - 10 business days* |
43.00€
|
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Cay11138-5 | 5 g | - |
6 - 10 business days* |
164.00€
|
2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate... more
Product information "2,4-Pyridinedicarboxylic Acid (hydrate)"
2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate (2-OG, also known as alpha-ketoglutarate) and chelates zinc, thus affecting a range of enzymes. As a 2-OG mimic, it blocks the activity of 2-OG oxygenases, which include certain lysine demethylases and a variety of hydroxylases (e.g., prolyl, collagen, lysyl). 2,4-PDCA inhibits several Jumonji domain-containing lysine demethylases when used at low micromolar concentrations. Through its effects on hydroxylases, including prolyl hydroxlase 1 (IC50 = 1.5 µM), 2,4-PDCA modulates hypoxia-inducible factor turnover, collagen synthesis, and plant cell wall formation. It can inhibit zinc-dependent enzymes, like metallo-beta-lactamase. 2,4-PDCA also affects and is translocated by organic anion transporters.Formal Name: 2,4-pyridinedicarboxylic acid, monohydrate. CAS Number: 207671-42-9. Synonyms: 2,4-Dicarboxylpyridine, 2,4-PDCA. Molecular Formula: C7H5NO4 . H2O. Formula Weight: 185.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 1.4 mg/ml, PBS (pH 7.2): 0.2 mg/ml. lambdamax: 204, 277 nm. SMILES: OC(C1=NC=CC(C(O)=O)=C1)=O.O. InChi Code: InChI=1S/C7H5NO4.H2O/c9-6(10)4-1-2-8-5(3-4)7(11)12,/h1-3H,(H,9,10)(H,11,12),1H2. InChi Key: PLNFTNOXJDBMSM-UHFFFAOYSA-N.
Keywords: | 2,4-Dicarboxylpyridine, 2,4-PDCA, 2,4-pyridinedicarboxylic acid, monohydrate |
Supplier: | Cayman Chemical |
Supplier-Nr: | 11138 |
Properties
Application: | 2-OG oxygenase inhibitor |
MW: | 185.1 D |
Formula: | C7H5NO4 . H2O |
Purity: | >98% |
Format: | Crystalline Solid |
Database Information
CAS : | 207671-42-9| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
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H Phrases: | H315, H319, H335 |
P Phrases: | P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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