2,4-Pyridinedicarboxylic Acid (hydrate)

2,4-Pyridinedicarboxylic Acid (hydrate)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay11138-1 1 g -

6 - 10 business days*

43.00€
Cay11138-5 5 g -

6 - 10 business days*

164.00€
 
2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate... more
Product information "2,4-Pyridinedicarboxylic Acid (hydrate)"
2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate (2-OG, also known as alpha-ketoglutarate) and chelates zinc, thus affecting a range of enzymes. As a 2-OG mimic, it blocks the activity of 2-OG oxygenases, which include certain lysine demethylases and a variety of hydroxylases (e.g., prolyl, collagen, lysyl). 2,4-PDCA inhibits several Jumonji domain-containing lysine demethylases when used at low micromolar concentrations. Through its effects on hydroxylases, including prolyl hydroxlase 1 (IC50 = 1.5 µM), 2,4-PDCA modulates hypoxia-inducible factor turnover, collagen synthesis, and plant cell wall formation. It can inhibit zinc-dependent enzymes, like metallo-beta-lactamase. 2,4-PDCA also affects and is translocated by organic anion transporters.Formal Name: 2,4-pyridinedicarboxylic acid, monohydrate. CAS Number: 207671-42-9. Synonyms: 2,4-Dicarboxylpyridine, 2,4-PDCA. Molecular Formula: C7H5NO4 . H2O. Formula Weight: 185.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 1.4 mg/ml, PBS (pH 7.2): 0.2 mg/ml. lambdamax: 204, 277 nm. SMILES: OC(C1=NC=CC(C(O)=O)=C1)=O.O. InChi Code: InChI=1S/C7H5NO4.H2O/c9-6(10)4-1-2-8-5(3-4)7(11)12,/h1-3H,(H,9,10)(H,11,12),1H2. InChi Key: PLNFTNOXJDBMSM-UHFFFAOYSA-N.
Keywords: 2,4-Dicarboxylpyridine, 2,4-PDCA, 2,4-pyridinedicarboxylic acid, monohydrate
Supplier: Cayman Chemical
Supplier-Nr: 11138

Properties

Application: 2-OG oxygenase inhibitor
MW: 185.1 D
Formula: C7H5NO4 . H2O
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 207671-42-9| Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319, H335
P Phrases: P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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