2,4-DPD

The pro-angiogenic factor HIF-1alpha is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-alpha prolyl hydroxylase (HIF-PH). 2,4-DPD is a cell permeable, competitive inhibitor of HIF-PH. 2,4-DPD inhibits the hydroxylation of P564 by acting as a competitive inhibitor of the HIF-PH cofactor alpha-keto glutarate, with effective concentrations in the low µM range. 2,4-DPD is therefore expected to act as a pro-angiogenic compound, via the HIF-1alpha system.Formal Name: 2,4-pyridinedicarboxylic acid, diethyl ester. CAS Number: 41438-38-4. Synonyms: 2,4-Diethylpyridine dicarboxylate. Molecular Formula: C11H13NO4. Formula Weight: 223.2. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 30 mg/ml, DMSO: 20 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: O=C(OCC)C1=NC=CC(C(OCC)=O)=C1. InChi Code: InChI=1S/C11H13NO4/c1-3-15-10(13)8-5-6-12-9(7-8)11(14)16-4-2/h5-7H,3-4H2,1-2H3. InChi Key: MUUDQLHCIAOWPR-UHFFFAOYSA-N.