20-HETE-d6

20-HETE-d6 contains six deuterium atoms at the 16, 16', 17, 17', 18 and 18' positions. It is intended for use as an internal standard for the quantification of 20-HETE (Cay-90030) by GC- or LC-MS. 20-HETE is a cytochrome P450 (CYP450) metabolite postulated to play an autacoid role in the renal and cerebral vasculature. In rat cerebral microvessels, 20-HETE is a vasoconstrictor that mediates pressure-induced autoregulatory vasoconstriction. 20-HETE is excreted mainly as the glucuronide conjugate. The concentration of free 20-HETE (20-40 pg/ml in human urine) is about 10-fold lower than the corresponding concentration of the 20-glucuronide.Formal Name: 20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic-16,16,17,17,18,18-d6 acid. CAS Number: 2548939-89-3. Synonyms: 20-Hydroxyeicosatetraenoic Acid-d6, 20-hydroxy Arachidonic Acid-d6. Molecular Formula: C20H26D6O3. Formula Weight: 326.5. Purity: >99% deuterated forms (d1-d6). Formulation: (Request formulation change), A solution in acetonitrile. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 500 µg/ml. SMILES: OCCC([2H])([2H])C([2H])([2H])C([2H])([2H])/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O. InChi Code: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10-/i11D2,13D2,15D2. InChi Key: NNDIXBJHNLFJJP-KVJJYFOZSA-N.