2-hexyl-4-Pentynoic Acid

2-hexyl-4-Pentynoic acid is a derivative of valproic acid (Cay-13033), an inhibitor of histone deacetylases (HDACs). It inhibits HDAC activity more potently (IC50 = 13 µM) than valproic acid (IC50 = 398 µM). 2-hexyl-4-Pentynoic acid induces histone hyperacetylation in cerebellar granule cells significantly at 5 µM. It also induces the expression of heat shock proteins Hsp70-1a and Hsp70-1b and protects cerebellar granule cells from glutamate-induced excitotoxicity when used at a concentration of 50 µM.Formal Name: 2-(2-propyn-1-yl)-octanoic acid. CAS Number: 96017-59-3. Molecular Formula: C11H18O2. Formula Weight: 182.3. Purity: >95%. Formulation: (Request formulation change), A neat oil. Solubility: DMF: 16 mg/ml, DMSO: 20 mg/ml, Ethanol: 33 mg/ml, PBS (pH 7.2): 2 mg/ml. SMILES: C#CCC(C(O)=O)CCCCCC. InChi Code: InChI=1S/C11H18O2/c1-3-5-6-7-9-10(8-4-2)11(12)13/h2,10H,3,5-9H2,1H3,(H,12,13). InChi Key: DUQSBRQHALCSLC-UHFFFAOYSA-N.