Tranylcypromine (hydrochloride)

Tranylcypromine is an irreversible, mechanism-based inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 20.7 µM in a cell-free assay). It also irreversibly inhibits monoamine oxidase A (MAO-A) and MAO-B with IC50 values of 2.3 and 0.95 µM, respectively. Tranylcypromine inhibits nucleosomal demethylation of histone H3 lysine 4 (H3K4, IC50 = 13122) to promote the differentiation of keratinocytes into induced pluripotent stem cells (iPSCs) when transduced with the transcription factors Oct4 and Klf4. It also decreases proliferation of neural progenitors in the hippocampal dentate gyrus in adult mice when administered at a dose of 10 mg/kg for ten days. Tranylcypromine (0.5-10 mg/kg) decreases the time juvenile rats spend immobile in the forced swim test, indicating antidepressant-liked activity. Formulations containing tranylcypromine have been used in the treatment of treatment-resistant major depressive disorder.Formal Name: (1R,2S)-rel-2-phenyl-cyclopropanamine, monohydrochloride. CAS Number: 1986-47-6. Synonyms: 2-PCPA, trans-2-Phenylcyclopropylamine. Molecular Formula: C9H11N . HCl. Formula Weight: 169.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMSO: 2.5 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 2 mg/ml. SMILES: N[C@@H]1CC1c1ccccc1. InChi Code: InChI=1S/C9H11N.ClH/c10-9-6-8(9)7-4-2-1-3-5-7,/h1-5,8-9H,6,10H2,1H/t8-,9+,/m0./s1. InChi Key: ZPEFMSTTZXJOTM-OULXEKPRSA-N.