2-Methoxyestradiol EIA Kit (strips)
ART NR.: Cay582261-480 (480 st-wells)
Schlagworte: 2-Hydroxyestradiol 2-methyl ester, 2-ME2
2-Methoxyestradiol (2-ME2) is a natural metabolite of estradiol produced by CYP450-dependant hydroxylation followed by catechol-O-methyltransferase-catalyzed O-methylation. Deficiency in catechol-O-methyltransferase is associated with pre-eclampsia. Therefore, 2-ME2 may be utilized as a plasma and urinary diagnostic marker for this disease, as well as a therapeutic supplement for its prevention. Several clinical trials have demonstrated the antitumor effects of 2-ME2 in prostate cancer, breast cancer, renal cell carcinoma, ovarian cancer, glioblastoma, and multiple myeloma. Other studies indicate that 2-ME2 exhibits more potent cardioprotective effects than estradiol. Cayman's 2-Methoxyestradiol EIA Kit is a competitive assay that can be used for quantification of 2-ME2 in plasma, urine, and other sample matrices.
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