9 products were found matching "Cay37730"!

15-OxoEDE is produced by the oxidation of 15-HEDE. 15-OxoEDE inhibits 5-LO from RBL-1 cells with an IC50 of 55 µM, which is about 2-fold lower than 15(S)-HEDE. A related oxo-eicosanoid, 5-oxoETE, is biosynthesized from 5(S)-HETE by a specific dehydrogenase and has potent inflammatory activity.Formal Name:...

CA77.1 is an inducer of chaperone-mediated autophagy (CMA). It induces the formation of autophagic lysosomes in NIH3T3 cells expressing a CMA reporter when used at concentrations of 10, 20, and 30 µM. CA77.1 (20 µM) induces autophagic flux in NIH3T3 cells. In vivo, CA77.1 (30 mg/kg) reduces locomotor hyperactivity...

ETP-46321 is an inhibitor of PI3K p110alpha and p110delta (apparent Kis = 2.3 and 14.2 nM, respectively). It is selective for PI3K p110alpha and p110delta over p110beta and p110gamma (apparent Kis = 170 and 179 nM, respectively), as well as a panel of 288 kinases at 1 µM. ETP-46321 inhibits Akt phosphorylation in...

Fulacimstat is an inhibitor of chymase (IC50s = 4 and 3 nM for the human and hamster enzyme, respectively). It reduces cardiac fibrosis induced by the beta1-adrenergic receptor (B1-AR) and beta2-AR agonist isoprenaline (isoproterenol, Cay-15592) in hamsters when administered at doses of 1, 3, and 10 mg/kg....

Lentztrehalose C is a disaccharide that has been found in Lentzea and has autophagy-inducing activity. It induces autophagy in MeWo melanoma and OVK18 ovarian cancer cells when used at a concentration of 100 mM.Formal Name: alpha-D-glucopyranosyl...

HM43239 is an inhibitor of wild-type (WT) and internal tandem duplication (ITD) mutant FMS-related tyrosine kinase 3 (FLT3, IC50s = 1.1 and 1.8 nM, respectively). It also inhibits VEGFR2 and spleen tyrosine kinase (Syk) by 100 and 95%, respectively, when used at a concentration of 100 nM. HM43239 inhibits the growth...

Lentztrehalose A is a disaccharide microbial metabolite that has been found in Lentzea and has diverse biological activities. It selectively inhibits M. smegmatis trehalase, a trehalose metabolizing enzyme, over porcine kidney trehalase (IC50s = 0.67 and >20 mM, respectively). Lentztrehalose A (100 mM) induces...

Lentztrehalose B is a disaccharide microbial metabolite that has been found in Lentzea and has diverse biological activities. It has antioxidant activity in an oxygen radical absorbance capacity (ORAC) assay when used at a concentration of 100 µM. Lentztrehalose B (10 mM) inhibits the activity of porcine kidney...

Necrostatin-34 is an inhibitor of receptor-interacting serine/threonine kinase 1 (RIPK1, IC50 = 5.5 µM). It inhibits TNF-alpha-induced necroptosis in Jurkat cells lacking Fas-associated death domain protein (FADD) and L-929 cells (IC50s = 6.67 and 1.35 µM, respectively). Necrostatin-34 (10 µM) inhibits necroptosis...