Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay10011263-100 | 100 µg | - |
6 - 10 business days* |
642.00€
|
Two types of 15-lipoxygenase (15-LO) have been discovered and characterized, both of which... more
Product information "15-Lipoxygenase-2 (human, recombinant)"
Two types of 15-lipoxygenase (15-LO) have been discovered and characterized, both of which metabolize arachidonic acid (AA) to produce 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE). 15-LO-1 oxygenates AA at both C-15 and C-12, whereas 15-LO-2 exclusively oxygenates C-15 of AA. Human 15-LO-2 has a molecular mass of approximately 76 kDa and exhibits approximately 40% identity to the reticulocyte 15-LO-1. Expression of 15-LO-2 appears to be restricted to prostate, lung, skin, and cornea and may play a role in the normal development of these tissues. The protein levels and enzymatic activity of 15-LO-2 are both down-regulated in prostate cancer compared with normal and benign prostate tissues, implicating a possible protective role for 15-LO-2 against tumor formation. Cayman's 15-LO-2 (human, recombinant) is expressed and purified from E. coli. The purity was determined using gel electrophoresis followed by coomassie staining. 15-LO-2 specific activity was established using arachidonic acid as the substrate and monitoring diene formation by measuring absorbance 236 nm.Synonyms: 15-LOX-2, 15-LO-2. Purity: >85% estimated by SDS-PAGE. Source: Active human recombinant C-terminal His-tagged protein expressed in E. coli. MW: 76 kDa. Formulation: (Request formulation change), PBS, pH 7.5, with 1 mM DTT, 20% glycerol. UniProt Accession #: O15296.
Keywords: | 15-LOX-B, 15-LOX-B, Arachidonate 15-lipoxygenase B, Arachidonate 15-lipoxygenase B, Linoleate 13-lipoxygenase 15-LOb, Linoleate 13-lipoxygenase 15-LOb, Arachidonate 15-lipoxygenase type II, Arachidonate 15-lipoxygenase type II, 15-LOX-2 {ECO:0000303|PubMe |
Supplier: | Cayman Chemical |
Supplier-Nr: | 10011263 |
Properties
Application: | Enzyme activity |
Conjugate: | No |
MW: | 76 kD |
Purity: | >85% estimated by SDS-PAGE |
Format: | Solution |
Database Information
KEGG ID : | K08022 | Matching products |
UniProt ID : | O15296 | Matching products |
Gene ID | GeneID 247 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
|
H Phrases: | H316, H319 |
P Phrases: | P264, P280, P305+351+338, P332+313, P337+313 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed