1,4-PBIT (dihydrobromide)

1,4-PBIT is a potent inhibitor of purified human iNOS and nNOS with Ki values of 7.4 and 16 nM, respectively, compared to a Ki of 360 nM for human eNOS. Its inhibition in whole cells is greatly diminished, presumably to poor membrane permeability.Formal Name: S,S'-1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea, dihydrobromide. CAS Number: 157254-60-9. Molecular Formula: C12H18N4S2 . 2HBr. Formula Weight: 444.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 25 mg/ml, PBS (pH 7.2): 5 mg/ml. SMILES: N/C(SCCC1=CC=C(CCS/C(N)=N/[H])C=C1)=N/[H].Br.Br. InChi Code: InChI=1S/C12H18N4S2.2BrH/c13-11(14)17-7-5-9-1-2-10(4-3-9)6-8-18-12(15)16,,/h1-4H,5-8H2,(H3,13,14)(H3,15,16),2*1H. InChi Key: YRRYHMLYGVNPBW-UHFFFAOYSA-N.