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Product information "13,14-dihydro Prostaglandin E1"
13,14-dihydro Prostaglandin E1 (13,14-dihydro PGE1) is a biologically active metabolite of PGE1 with comparable potency to the parent compound. It is an inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 31 and 21 nM, respectively. 13,14-dihydro PGE1 is a slightly more potent inhibitor of ADP-induced human platelet aggregation than PGE1 (Cay-13010) which has an IC50 value of 40 nM. Also, 13,14-dihydro PGE1 was shown to activate adenylate cyclase in NCB-20 hybrid cells with a Kact value of 668 nM.Formal Name: 9-oxo-11alpha,15S-dihydroxy-prostan-1-oic acid. CAS Number: 19313-28-1. Synonyms: PGE0, 13,14-dihydro PGE1. Molecular Formula: C20H36O5. Formula Weight: 356.5. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: >100 mg/ml, DMSO: >50 mg/ml, Ethanol: >50 mg/ml, PBS (pH 7.2): >1.6 mg/ml. SMILES: O=C1[C@H](CCCCCCC(OC)=O)[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C1. InChi Code: InChI=1S/C21H38O5/c1-3-4-7-10-16(22)13-14-18-17(19(23)15-20(18)24)11-8-5-6-9-12-21(25)26-2/h16-18,20,22,24H,3-15H2,1-2H3/t16-,17+,18+,20+/m0/s1. InChi Key: WWCDWHSPGWIYEH-JRBPQWBISA-N.
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