12 products were found matching "Cay10009898"!

11beta-Prostaglandin F2alpha-d4 (11beta-PGF2alpha-d4) is intended for use as an internal standard for the quantification of 11beta-PGF2alpha (Cay-16520) by GC- or LC-MS. 11beta-PGF2alpha is the primary metabolite of PGD2 (Cay-12010). It is formed from PGD2 via the NADPH-dependent aldo-keto reductase PGF synthase...

CD36, also known as scavenger receptor B2 or fatty acid translocase, is a transmembrane glycoprotein that has roles in fatty acid uptake and lipid metabolism and signaling. It is composed of N- and C-terminal cytoplasmic tails, two transmembrane domains, and an extracellular loop that binds to a variety of lipid...

Formulation: 4% formaldehyde solution in TBS, pH 7.4.

Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Controlling bacterial infections by quenching their quorum sensing systems is a promising field of study. The expression of specific target genes, such as transcriptional regulators...

(±)8(9)-DiHET-d11 is intended for use as an internal standard for the quantification of 8(9)-DiHET by GC- or LC-MS. 8(S),9(S)-DiHET and 8(R),9(R)-DiHET are vicinal diols formed via enzymatic hydration of 8(9)-EET by cytosolic or soluble epoxide hydrolases. 8(S),9(S)-DiHET is produced at a greater proportion than...

EX-527 is an inhibitor of sirtuin 1 (SIRT1, IC50 = 0.098 µM). It is selective for SIRT1 over SIRT2, and SIRT3 (IC50s = 19.6 and 48.7 µM, respectively) and the cytochrome P450 (CYP) isoforms CYP3A4, CYP2D6, CYP2C9, CYP2C19, and CYP1A2 at 1 µM. EX-527 (50 µM) induces cell cycle arrest at the G1 phase in MCF-7...

PD 166326 is a pyridopyrimidine-type inhibitor of receptor tyrosine kinases that inhibits c-abl (IC50 = 8 nM) and Bcr/Abl-dependent cell growth (IC50 = 0.4 nM). In addition to targeting a select group of receptor tyrosine kinases, PD 166326 also potently inhibits c-src (IC50 = 6 nM). Orally administered PD 166326 is...

The NF-kappaB/Rel family of transcription factors is comprised of several structurally-related proteins that form homodimers and heterodimers and include p50/p105, p52/p100, RelA (p65), and c-Rel/NF-kappaB . Members of this family are responsible for regulating over 150 target genes, including the expression of...

6,7-dihydroxy Bergamottin (6,7-DHB) is a potent inhibitor of CYP3A4 (IC50 = 25 µM). It appears to be the primary compound in grapefruit juice that is responsible for inhibition of testosterone 6beta-hydrolase activity. Ingestion of grapefruit juice during treatment regimes with drugs normally metabolized by...

TPH catalyzes the 5-hydroxylation of tryptophan, which is the first step in the biosynthesis of indoleamines (serotonin and melatonin). In mammals, serotonin biosynthesis occurs predominantly in neurons which originate in the Raphe nuclei of the brain, and melatonin synthesis takes place within the pineal gland. TPH...

This antibody has been specifically formulated to be used in the CREB (Phospho-Ser133) Transcription Factor Assay Kit (Cay-10009846). Prepare the primary antibody diluting 1:100 in 1X Antibody Binding Buffer (ABB) as outlined below. Add 100 µl of diluted CREB (Phospho-Ser133) antibody to each well except the Blank...

Formulation: 20 ml of TBS buffer, pH 7.4.