10058-F4

The Myc proto-oncogenes interact with Max to form a dimer that regulates gene transcription. The protein c-Myc, in particular, promotes gene expression relevant to cell growth and thus drives cancer. 10058-F4 is a cell-permeable thiazolidinone that inhibits the dimerization of c-Myc and Max at 64 µM, preventing c-Myc-dependent gene expression and cell proliferation. It induces cell cycle arrest, apoptosis, and myeloid differentiation at 100 µM in human acute myeloid leukemia cells. 10058-F4 is rapidly metabolized in mice when given intravenously, limiting its effects on tumors in vivo. In addition to c-Myc, 10058-F4 inhibits the nuclear Myc protein, N-Myc, at 50 µM, inducing arrest, apoptosis, and differentiation in neuroblastoma cells overexpressing the gene for N-Myc. This compound can be used to delineate novel actions of Myc proteins, especially those related to lipid and glucose metabolism.Formal Name: 5-[(4-ethylphenyl)methylene]-2-thioxo-4-thiazolidinone. CAS Number: 403811-55-2. Molecular Formula: C12H11NOS2. Formula Weight: 249.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 25 mg/ml, Ethanol: 0.3 mg/ml. lambdamax: 233, 277, 379 nm. SMILES: CCC1=CC=C(/C=C2C(NC(S\2)=S)=O)C=C1. InChi Code: InChI=1S/C12H11NOS2/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)/b10-7+. InChi Key: SVXDHPADAXBMFB-JXMROGBWSA-N.