1-Deoxynojirimycin (hydrochloride)

1-Deoxynojirimycin (1-DNJ) is an iminosugar that has been found in M. alba (mulberry) leaves and has diverse biological activities. It inhibits the activities of alpha- and beta-glucosidase (IC50s = 35 and 71 µM, respectively). 1-DNJ (5 mM) reduces the formation of N-linked complex oligosaccharides in IEC-6 cells. It inhibits HIV-1 envelope-mediated membrane fusion in CEM cells when used at a concentration of 2 mM. 1-DNJ (1-100 µg/ml) reduces the invasion and migration of B16/F10 mouse melanoma cells. It improves glucose and insulin tolerance in db/db mice when administered intravenously at doses ranging from 20 to 80 mg/kg per day for four weeks.Formal Name: 2R-(hydroxymethyl)-3R,4R,5S-piperidinetriol, monohydrochloride. CAS Number: 73285-50-4. Synonyms: 1-DNJ, 1-dNM, Moranoline. Molecular Formula: C6H13NO4 . HCl. Formula Weight: 199.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 10 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: O[C@H]1[C@H](O)[C@@H](O)CN[C@@H]1CO.Cl. InChi Code: InChI=1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3,/h3-11H,1-2H2,1H/t3-,4+,5-,6-,/m1./s1. InChi Key: ZJIHMALTJRDNQI-VFQQELCFSA-N. Origin: Synthetic.