1-(1-Naphthyl)piperazine (hydrochloride)

1-(1-Naphthyl)piperazine (1-NP) is a ligand for serotonin (5-hydroxytryptamine, 5-HT) receptors. It acts as an antagonist for 5-HT at 5-HT1 and 5-HT2 in rat cortical membranes with IC50 values of 6 and 1 nM, respectively. 1-NP also blocks contraction in the rat fundus induced by either 5-HT or tryptamine (IC50 = 1 nM for both agonists). 1-NP mimics the 5-HT1 agonist 1-(m-trifluoromethylphenyl)piperazine (TFMPP, Cay-11205) in decreasing 5-HT receptor turnover and increasing serum corticosterone, suggesting that, in the absence of 5-HT, 1-NP may act as an agonist of the 5-HT1 receptor. However, in squirrel monkeys, 1-NP acts as a non-selective 5-HT receptor antagonist in altering operant behavior. 1-NP also binds to the human 5-HT6 receptor with an affinity comparable to that of 5-HT (Kis = 120 and 100 nM, respectively).Formal Name: 1-(1-naphthalenyl)-piperazine, monohydrochloride. CAS Number: 104113-71-5. Synonyms: 1-NP. Molecular Formula: C14H16N2 . HCl. Formula Weight: 248.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 20 mg/ml, Ethanol: 25 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 216, 302 nm. SMILES: C1(C(N2CCNCC2)=CC=C3)=C3C=CC=C1.Cl. InChi Code: InChI=1S/C14H16N2.ClH/c1-2-6-13-12(4-1)5-3-7-14(13)16-10-8-15-9-11-16,/h1-7,15H,8-11H2,1H. InChi Key: ZYVYPNZFOCZLEM-UHFFFAOYSA-N.