- Search results for Cay10006794-100
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10 products were found matching "Cay10006794-100"!
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Item number: Cay10006790-1
ChREBP (carbohydrate response element-binding protein) is a transcription factor playing a critical role in the nutrient and hormonal regulation of genes encoding enzymes of glucose metabolism and lipogenesis pathways. It contains several domains including a nuclear localization signal (NSL) near the N-terminus,...
Keywords: | Carbohydrate Response Element-binding Protein, WBSCR14 |
Application: | Blocking |
177.00€
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Item number: Cay10006797-100
Xestospongins and araguspongins are marine natural products first isolated from Pacific basin sponges, and noted to have vasodilatory properties. Inositol phosphates (IP) are important signal transduction messengers acting via IP3 receptors to promote the mobilization of Ca2+ from intracellular stores. Araguspongin...
Keywords: | [1R-(1R*,4aR*,11S*,12aR*,13R*,16aR*,23S*,24aR*)]-eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,... |
Application: | IP3 receptor antagonist |
CAS | 123000-02-2 |
MW: | 446.7 D |
From 533.00€
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Item number: Cay10006974-10
AM630 binds selectively to cannabinoid 2 (CB2) over CB1 receptors with Ki values of 31.2 and 5,152 nM, respectively. AM630 acts as an inverse agonist at CB2 receptors, attenuating the antinociceptive effects of a number of cannabinoids, and as a weak partial agonist at CB1 receptors. It decreases proliferation and...
Keywords: | 6-Iodopravodoline, [6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)-methanone |
Application: | CB2 receptor antagonist |
CAS | 164178-33-0 |
MW: | 504.4 D |
From 77.00€
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COVID-19 Research
Item number: Cay10007964-10
E-64c is an active metabolite of the protease inhibitor E-64d (Cay-13533). E-64c inhibits the cysteine proteases cathepsin B, cathepsin H, and papain but not the serine proteases trypsin, chymotrypsin, or elastase. It reduces the autocatalytic activity of the foot-and-mouth-disease virus (FMDV) leader protease when...
Keywords: | Loxistatin Acid, NSC 694279,... |
Application: | Cysteine protease inhibitor |
CAS | 76684-89-4 |
MW: | 314.4 D |
From 84.00€
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Lipid-based Drug Delivery Tools
Item number: Cay10007946-10
C16 Sphingomyelin is a naturally occurring sphingolipid. Levels of C16 sphingomyelin are elevated in the prefrontal cortex and cerebellum in a rat model of diabetes induced by streptozotocin (STZ, Cay-13104), as well as in the liver in mouse models of Niemann-Pick type C1 disease. Plasma levels of C16 sphingomyelin...
Keywords: | N-Palmitoyl-D-erythro-Sphingosylphosphorylcholine, Palmitoyl Sphingomyelin, SM(d18:1/16:0), Sphingomyelin (d18:1/16:0),... |
Application: | Bioactive Lipid Assays |
CAS | 6254-89-3 |
MW: | 703 D |
From 94.00€
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Item number: Cay10007904-10
2-Arachidonoyl glycerol (2-AG) is an endogenous agonist of the central cannabinoid (CB1) receptor. It is present at relatively high levels in the central nervous system and is the most abundant molecular species of monoacylglycerol found in rat brain. Monoacylglycerol lipase (MAGL) hydrolyzes 2-AG to arachidonic...
Keywords: | 1-S-Arachidonoyl-1-mercapto-2,3-propanediol, 5Z,8Z,11Z,14Z-eicosatetraenyl,1-thio glycerol |
Application: | Bioactive lipid assays |
CAS | 1309664-54-7 |
MW: | 394.6 D |
From 39.00€
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Item number: Cay16794-100
(R)-Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) and an isomer of (±)-ibuprofen (Cay-70280). Unlike (S)-ibuprofen (Cay-16793), (R)-ibuprofen does not inhibit COX-1 or COX-2 in vitro (IC50s = 360 and 15.6 µM, respectively) but is converted to the active (S)-enantiomer in vivo. It inhibits NF-kappaB...
Keywords: | (-)-Ibuprofen, alpha-methyl-4-(2-methylpropyl)-(alphaR)-benzeneacetic acid |
Application: | NF-kappaB activation inhibitor |
CAS | 51146-57-7 |
MW: | 206.3 D |
From 104.00€
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Item number: Cay10006594-100
Losartan is an antagonist of angiotensin II type 1b (AT1b) receptor (IC50 = 2.2 nM in COS-7 cells expressing the rat receptor). It reduces U-46619-induced aggregation of platelets in isolated human platelet-rich plasma when used at a concentration of 5 µM. It decreases 1-lipoxygenase (1-LO) levels in the endothelial...
Keywords: | DuP-753, MK 954, 2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol,... |
Application: | AT1 receptor antagonist |
CAS | 124750-99-8 |
MW: | 461 D |
From 23.00€
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Item number: Cay16704-100
Eicosapentaenoic acid (EPA, Cay-90110) is an omega-3 fatty acid abundantly available in marine organisms that has been shown to offer anti-inflammatory and cardiovascular benefits. EPA alkyne is a form of EPA with an omega-terminal alkyne. The terminal alkyne group can be used in click chemistry linking reactions to...
Keywords: | Click Tag(TM) EPA Alkyne, EPA Alkyne, 5Z,8Z,11Z,14Z,17Z-eicosapentaen-19-ynoic acid |
Application: | EPA derivative, click chemistry |
MW: | 298.4 D |
From 316.00€
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Item number: Cay16094-100
(-)-Apomorphine is a non-selective dopamine receptor agonist that exhibits pKi values of 6.43, 7.08, 7.59, 8.36, and 7.83 for human recombinant D1, D2L, D3, D4, and D5 receptors, respectively. It produces biphasic effects on locomotor activity and displays anti-Parkinsonian and neuroprotective actions.Formal Name:...
Keywords: | NSC 11442, Uprima, 5,6,6aR,7-tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol, monohydrochloride |
Application: | Dopamine receptor agonist |
CAS | 58117-94-5 |
MW: | 303.8 D |
From 43.00€
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