10 products were found matching "Cay10006794-100"!

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ChREBP Blocking Peptide
ChREBP Blocking Peptide

Item number: Cay10006790-1

ChREBP (carbohydrate response element-binding protein) is a transcription factor playing a critical role in the nutrient and hormonal regulation of genes encoding enzymes of glucose metabolism and lipogenesis pathways. It contains several domains including a nuclear localization signal (NSL) near the N-terminus,...
Keywords: Carbohydrate Response Element-binding Protein, WBSCR14
Application: Blocking
177.00€ *
Review
Araguspongin B
Araguspongin B

Item number: Cay10006797-100

Xestospongins and araguspongins are marine natural products first isolated from Pacific basin sponges, and noted to have vasodilatory properties. Inositol phosphates (IP) are important signal transduction messengers acting via IP3 receptors to promote the mobilization of Ca2+ from intracellular stores. Araguspongin...
Keywords: [1R-(1R*,4aR*,11S*,12aR*,13R*,16aR*,23S*,24aR*)]-eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,...
Application: IP3 receptor antagonist
CAS 123000-02-2
MW: 446.7 D
From 533.00€ *
Review
AM630
AM630

Item number: Cay10006974-10

AM630 binds selectively to cannabinoid 2 (CB2) over CB1 receptors with Ki values of 31.2 and 5,152 nM, respectively. AM630 acts as an inverse agonist at CB2 receptors, attenuating the antinociceptive effects of a number of cannabinoids, and as a weak partial agonist at CB1 receptors. It decreases proliferation and...
Keywords: 6-Iodopravodoline, [6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)-methanone
Application: CB2 receptor antagonist
CAS 164178-33-0
MW: 504.4 D
From 77.00€ *
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COVID-19 Research
E-64c
E-64c

Item number: Cay10007964-10

E-64c is an active metabolite of the protease inhibitor E-64d (Cay-13533). E-64c inhibits the cysteine proteases cathepsin B, cathepsin H, and papain but not the serine proteases trypsin, chymotrypsin, or elastase. It reduces the autocatalytic activity of the foot-and-mouth-disease virus (FMDV) leader protease when...
Keywords: Loxistatin Acid, NSC 694279,...
Application: Cysteine protease inhibitor
CAS 76684-89-4
MW: 314.4 D
From 84.00€ *
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Lipid-based Drug Delivery Tools
C16 Sphingomyelin (d18:1/16:0)
C16 Sphingomyelin (d18:1/16:0)

Item number: Cay10007946-10

C16 Sphingomyelin is a naturally occurring sphingolipid. Levels of C16 sphingomyelin are elevated in the prefrontal cortex and cerebellum in a rat model of diabetes induced by streptozotocin (STZ, Cay-13104), as well as in the liver in mouse models of Niemann-Pick type C1 disease. Plasma levels of C16 sphingomyelin...
Keywords: N-Palmitoyl-D-erythro-Sphingosylphosphorylcholine, Palmitoyl Sphingomyelin, SM(d18:1/16:0), Sphingomyelin (d18:1/16:0),...
Application: Bioactive Lipid Assays
CAS 6254-89-3
MW: 703 D
From 94.00€ *
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Arachidonoyl-1-thio-Glycerol
Arachidonoyl-1-thio-Glycerol

Item number: Cay10007904-10

2-Arachidonoyl glycerol (2-AG) is an endogenous agonist of the central cannabinoid (CB1) receptor. It is present at relatively high levels in the central nervous system and is the most abundant molecular species of monoacylglycerol found in rat brain. Monoacylglycerol lipase (MAGL) hydrolyzes 2-AG to arachidonic...
Keywords: 1-S-Arachidonoyl-1-mercapto-2,3-propanediol, 5Z,8Z,11Z,14Z-eicosatetraenyl,1-thio glycerol
Application: Bioactive lipid assays
CAS 1309664-54-7
MW: 394.6 D
From 39.00€ *
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(R)-Ibuprofen
(R)-Ibuprofen

Item number: Cay16794-100

(R)-Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) and an isomer of (±)-ibuprofen (Cay-70280). Unlike (S)-ibuprofen (Cay-16793), (R)-ibuprofen does not inhibit COX-1 or COX-2 in vitro (IC50s = 360 and 15.6 µM, respectively) but is converted to the active (S)-enantiomer in vivo. It inhibits NF-kappaB...
Keywords: (-)-Ibuprofen, alpha-methyl-4-(2-methylpropyl)-(alphaR)-benzeneacetic acid
Application: NF-kappaB activation inhibitor
CAS 51146-57-7
MW: 206.3 D
From 104.00€ *
Review
Losartan (potassium salt)
Losartan (potassium salt)

Item number: Cay10006594-100

Losartan is an antagonist of angiotensin II type 1b (AT1b) receptor (IC50 = 2.2 nM in COS-7 cells expressing the rat receptor). It reduces U-46619-induced aggregation of platelets in isolated human platelet-rich plasma when used at a concentration of 5 µM. It decreases 1-lipoxygenase (1-LO) levels in the endothelial...
Keywords: DuP-753, MK 954, 2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol,...
Application: AT1 receptor antagonist
CAS 124750-99-8
MW: 461 D
From 23.00€ *
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Eicosapentaenoic Acid Alkyne
Eicosapentaenoic Acid Alkyne

Item number: Cay16704-100

Eicosapentaenoic acid (EPA, Cay-90110) is an omega-3 fatty acid abundantly available in marine organisms that has been shown to offer anti-inflammatory and cardiovascular benefits. EPA alkyne is a form of EPA with an omega-terminal alkyne. The terminal alkyne group can be used in click chemistry linking reactions to...
Keywords: Click Tag(TM) EPA Alkyne, EPA Alkyne, 5Z,8Z,11Z,14Z,17Z-eicosapentaen-19-ynoic acid
Application: EPA derivative, click chemistry
MW: 298.4 D
From 316.00€ *
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(-)-Apomorphine (hydrochloride hydrate)
(-)-Apomorphine (hydrochloride hydrate)

Item number: Cay16094-100

(-)-Apomorphine is a non-selective dopamine receptor agonist that exhibits pKi values of 6.43, 7.08, 7.59, 8.36, and 7.83 for human recombinant D1, D2L, D3, D4, and D5 receptors, respectively. It produces biphasic effects on locomotor activity and displays anti-Parkinsonian and neuroprotective actions.Formal Name:...
Keywords: NSC 11442, Uprima, 5,6,6aR,7-tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol, monohydrochloride
Application: Dopamine receptor agonist
CAS 58117-94-5
MW: 303.8 D
From 43.00€ *
Review