(+)-MK-801 (hydrogen maleate)

MK-801 is a potent, selective and non-competitive N-methyl-D-aspartate (NMDA) (Cay-14581) receptor antagonist (Ki = 30.5 nM) that acts at the NMDA receptor-operated ion channel as an open channel blocker, preventing Ca2+ flux. It has been shown to be protective in various models of ischemia as well as to inhibit behavioral sensitization to certain psychostimulants.Formal Name: 10,11-dihydro-5S-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine, (2Z)-2-butenedioate. CAS Number: 77086-22-7. Synonyms: Dizocilpine. Molecular Formula: C16H15N . C4H4O4. Formula Weight: 337.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2) (1:9): 0.5 mg/ml, DMSO: 20 mg/ml, Ethanol: 0.5 mg/ml. SMILES: C[C@@]12C3=CC=CC=C3[C@@](N2)([H])CC4=CC=CC=C41.O=C(/C=C\C(O)=O)O. InChi Code: InChI=1S/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16,5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3,1-2H,(H,5,6)(H,7,8)/b,2-1-/t15-,16+,/m1./s1. InChi Key: QLTXKCWMEZIHBJ-PJGJYSAQSA-N. Origin: Synthetic.