(±)-C75

Inhibition of fatty acid synthase (FASN) by the irreversible inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines. (±)-C75 is a stable inhibitor of FASN that leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice. (±)-C75 is also cytotoxic to many human cancer cell lines, an effect believed to be mediated by the accumulation of malonyl-coenzyme A in cells with an upregulated FASN pathway.Formal Name: tetrahydro-4-methylene-2R-octyl-5-oxo-3S-furancarboxylic acid. CAS Number: 191282-48-1. Molecular Formula: C14H22O4. Formula Weight: 254.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 10 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): .5 mg/ml. lambdamax: 207 nm. SMILES: CCCCCCCC[C@H]1OC(=O)C(=C)C1C(=O)O. InChi Code: InChI=1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)/t11-,12?/m1/s1. InChi Key: VCWLZDVWHQVAJU-JHJMLUEUSA-N.