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(+)-Aphidicolin is a natural tetracyclic diterpene first isolated from the fungus C. aphidicola... more
Product information "(+)-Aphidicolin"
(+)-Aphidicolin is a natural tetracyclic diterpene first isolated from the fungus C. aphidicola and shown to have antiviral activity against herpes simplex. In eukaryotic cells, it is a cell-permeable, reversible inhibitor of DNA replication, specifically blocking the activity of DNA polymerases alpha, delta, and epsilon when used at low micromolar levels. Aphidicolin can be used, at 3 µM, to arrest cells in G1/S phase or to increase gene amplification frequency.Formal Name: (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol. CAS Number: 38966-21-1. Synonyms: ICI 69653, NSC 234714. Molecular Formula: C20H34O4. Formula Weight: 338.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 50 mg/ml, Methanol: 10 mg/ml. SMILES: O[C@]1(CO)CC[C@]23[C@@](C[C@@H]1C3)([H])CC[C@@]4([H])[C@@](CO)(C)[C@H](O)CC[C@@]42C. InChi Code: InChI=1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1. InChi Key: NOFOAYPPHIUXJR-APNQCZIXSA-N. Origin: Fungus/Phoma sp. BS 7210.
Keywords: | ICI 69653, NSC 234714, (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol |
Supplier: | Cayman Chemical |
Supplier-Nr: | 14007 |
Properties
Application: | Eucaryotic nuclear DNA replication inhibitor |
MW: | 338.5 D |
Formula: | C20H34O4 |
Purity: | >98% |
Format: | Solid |
Database Information
CAS : | 38966-21-1| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
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H Phrases: | H315, H319, H335 |
P Phrases: | P261, P264, P271, P280, P312, P321, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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