Anti-ARNTL, clone 1C5 / Product-Datasheet Pro-30033 |
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Biomol GmbH Waidmannstr. 35 22769 HAMBURG info@biomol.de www.biomol.de |
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Anti-ARNTL, clone 1C5 |
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| Specification | |
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| Entrez GeneID | 406 |
| Aliases | TIC; JAP3; MOP3; BMAL1; PASD3; BMAL1c; bHLHe5; MGC47515; ARNTL |
| Clone# | 1C5 |
| MW | 68.7kDa |
| Host/Isotype | Mouse IgG1 |
| Storage | 4℃; -20℃ for long term storage |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human ARNTL expressed in E. Coli.
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| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Application | |
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| WB | 1/500 - 1/2000 |
| IHC | 1/200 - 1/1000 |
| ICC | N/A |
| FCM | N/A |
| ELISA | 1/10000 |
| Description |
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The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes. Three transcript variants encoding two different isoforms have been found for this gene.
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| References |
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| 1. Chronobiol Int. 2007;24(5):783-92.
2. Mol Cell Biol. 2008 Oct;28(19):6056-65. 3. J Affect Disord. 2009 Sep;117(1-2):87-97. |
Figure 1: Western blot analysis using ARNTL mouse mAb against ARBTL(AA: 1-310)-hIgGFc transfected HEK293 cell lysate.
Figure 2: Immunohistochemical analysis of paraffin-embedded human Spleen tissues using anti-ARNTL mouse mAb