Anti-TLR8, ID (Toll-like Receptor 8, CD288, UNQ249/PRO286)Art Nr.: T8050-85L, USBio
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|Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. Like TLR7, TLR8 is localized to endosomal or lysosomal compartments and stimulates the innate immune response after activation by guanosine- and uridine-rich single-stranded RNA. Human but not murine TLR8 confers responsiveness to the antiviral compound R-848.|
|Applications||Suitable for use in ELISA, Western Blot and Immunocytochemistry. Other applications not tested.|
|Recommended Dilution||Western Blot: 0.5-2ug/ml|
|Optimal dilutions to be determined by the researcher.|
|Storage and Stability||May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.|
|Form||Supplied as a liquid in PBS, 0.02% sodium azide.|
|Purity||Purified by Ion Exchange chromatography.|
|Immunogen||Synthetic peptide corresponding to 16aa near the internal sequence of human TLR8.|
|Specificity||Recognizes human TLR8. Species Crossreactivity: mouse.|
|Important Note||This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.|
This product is offered by Biomol for research purposes only.
Not for diagnostic purposes or human use.
It may not be resold or used to manufacture commercial products without written approval of Biomol GmbH.