A23187, Ca-Mg

Art Nr.: LKT-A0102.10, LKT
Biomol GmbH
Waidmannstr. 35
22769 HAMBURG
info@biomol.de
www.biomol.de
Tel:+49-40 - 85 32 600
0800 - 24 66 651 free call
Fax: +49-40 - 85 32 60-22
0800 - 24 66 652 free call
A23187, Ca-Mg
A23187, Ca-Mg
Product No Price Quantity Subtotal
A0102-5mg $90.30
A0102-10mg $166.80
Total 
 
Description
A23187 is a Ca2+ ionophore that exhibits pro-inflammatory and allergic activities. In cardiomyocytes, A23187 induces formation of endothelial microvesicles, increasing leakage of lactate dehydrogenase and decreasing cell viability. A23187 also induces mast cell degranulation and increases production of TNF-α. In spermatozoa, this compound induces the acrosome reaction, allowing fertilization to occur in the absence of PKA activation.

Specifications

Product ID
A0102
Product Name
A23187, Ca-Mg
Formula Wt.
523.62
Purity
>98%, TLC
Solubility
Insoluble in water, hexane. Slightly soluble in ethanol, methanol. Soluble in choloform, acetone.
Store Temp
+4oC
References
Kim DY, Kang TB, Shim DW, et al. Emodin attenuates A23187-induced mast cell degranulation and tumor necrosis factor-α secretion through protein kinase C and IκB kinase 2 signaling. Eur J Pharmacol. 2014 Jan 15;723:501-6. PMID: 24239713.Shang M, Zhang Q, Zhang MX, et al. Effects of endothelial microvesicles induced by A23187 on H9c2 cardiomyocytes. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2013 Nov;29(6):559-64. PMID: 24654540.Tateno H, Krapf D, Hino T, et al. Ca2+ ionophore A23187 can make mouse spermatozoa capable of fertilizing in vitro without activation of cAMP-dependent phosphorylation pathways. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18543-8. PMID: 24128762.

This product is offered by Biomol for research purposes only. Not for diagnostic purposes or human use. It may not be resold or used to manufacture commercial products without written approval of Biomol GmbH.

close