Anti-DKK1 (Dickkopf-related Protein 1, Dickkopf-1, Dkk-1, hDkk-1, SK, UNQ492/PRO1008)Art Nr.: D3810-01M, USBio
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|DKK1 is a 266aa secreted protein with two cysteine rich regions and belonging to the dickkopf family. It is involved in embryonic development through its inhibition of the WNT signaling pathway and in the reentry into the cell cycle of human adult stem cells from bone marrow. Its loss of expression plays a role in development or progression of malignant melanoma. It decreases melanocyte function and is a key player in multiple myeloma bone disease. It is a potential prognostic and diagnostic marker for breast cancer patients with poor prognosis.|
|Applications||Suitable for use in Western Blot. Other applications not tested.|
|Recommended Dilution||Western Blot: 0.5-2ug/ml|
|Optimal dilutions to be determined by the researcher.|
|Positive Control||A549 and RAW cell lysate|
|Storage and Stability||May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.|
|Form||Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.|
|Purity||Purified by Protein G affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to aa150-200 of human DKK1.|
|Specificity||Recognizes human DKK1. Species sequence homology: mouse, rabbit.|
|Important Note||This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.|
This product is offered by Biomol for research purposes only.
Not for diagnostic purposes or human use.
It may not be resold or used to manufacture commercial products without written approval of Biomol GmbH.