PRMT9, human recombinant protein

Art Nr.: BPS-51053, BPS
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PRMT9

Catalog #: BPS-51053
Size: 20 µg
405
Species: Human
Host Species: Sf9 insect cells
MW: 95.9 kDa
Genbank #: NM_025133
Tag(s): N-terminal His-FLAG-tag
a.a: 2–843 (end)
Background:
PRMT9 (FBX11) can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This protein is down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. It is the substrate recognition component of the a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Description:
Human PRMT9 (GenBank Accession No. NM_025133), a.a. 2-843 (end), with N-terminal His-FLAG-tag, MW= 95.9 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
UniProt
Q6P2P2
Synonym(s):
PRMT9, Histone-arginine N-methyltransferase 9, FBX11, FBXO11, Protein Arginine N-Methyltransferase 9,Ubiquitin Protein Ligase E3 Component N-Recognin 6, VIT1, Viligo-Associated Protein, UBR6, F-Box Only Protein 11
Formulation:
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 200 mM imidazole, 20% glycerol and 3 mM DTT.
Format:
aqueous buffer solution
Storage / Stability:

>6 months at -80°C.

Application(s):
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s):
Cook, J.R., et al., Biochem. Biophys. Res. Commun. 342(2): 472-81 (2006).
Warning(s):
Avoid freeze/thaw cycles
Scientific Category:
Methyltransferase
Product Type:
Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
Qty:
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Quality Assurance

Product Datasheets

51053_Lot120913-FH.pdf

This product is offered by Biomol for research purposes only. Not for diagnostic purposes or human use. It may not be resold or used to manufacture commercial products without written approval of Biomol GmbH.

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