Cytokines are signaling proteins in cellular communication. While hormones are secreted from specific organs to the blood, and neurotransmitters are related to neural activity, the cytokines are a more diverse class of compounds in terms of origin and purpose. They are produced by a wide variety of hematopoietic and non-hematopoietic cell types and can have autocrine, paracrine and endocrine effects, sometimes strongly dependent on the presence of other chemicals. The cytokine family consists mainly of smaller, water-soluble proteins and glycoproteins with a mass between 8 and 30 kDa.
The term cytokine is used generically for interleukins, chemokines, growth factors, neurotrophins and similar extracellular proteinaceous ligands (lymphokines, monokines, interferons, colony-stimulating factors, immunomodulators, immunotransmitters, etc.). Cytokines can be isolated from natural sources or are recombinant and produced in bacteria, yeast or higher eukaryotic cells. Wheras bacterially expressed ones lack post-translational modifications, the latter are glycoproteins. In many assays non-glycosylated cytokines show a similar activity as glycosylated ones, for some studies glycosylation is important.
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About 400 of Biomol s cytokines are presented in this pdf document (102 kB).
Biomol offers a selection of affordable and easy-to-use ELISA kits for determination of concentration cytokines (and similar ligands).
Biomol offers also thousands of antibodies for the analysis of cytokines and similar ligands. New: Cytokine antibodies for veterinary research. New: Antibodies raised against authentic human cytokines.
New: Biomol offers a range of human cytokines, which have been recombinantly produced in human cell lines. They carry authentic glycosyslation making them more stable and active: More Info ...
Kingfisher Biotech, Inc. is committed to accelerating basic veterinary research and human disease research done in animal models by developing and commercializing research reagents specific for a variety of species previously underserved in the commercial market: Bovine (Cattle, Cow, Ox, Bull, Bos taurus) Canine (Dog, Canis lupus familiaris) Chicken (Cock, Hen, Gallus gallus domesticus) Equine (Horse, Equus ferus caballus) Feline (Cat, Felis catus) Rabbit (Bunny, buck, doe, coney, Oryctolagus cuniculus) Swine (Pig, Porcine, Sus domestica) Turkey (hen, poult, tom, stag, Meleagris gallopavo)
Biomol presents a search engine for finding cytokines: Search and find Cytokines
Read up-to-date cytokine news at twitter.com/cytokines
Human cell expressed recombinant humen cytokines with high activity, authentic folding, multimerisation and glycosylation. And very attractively priced. More ...
Clean and glycosylated cytokines (very low endotoxin) expressed in plants (barley grain): bio-clean cytokines.
4-1BB Ligand Activin A Adiponectin (Acrp30) AITRL Angiopoietin-1 Angiopoietin-2 Angiopoietin-like Protein-3 Angiopoietin-like Protein-4 Apolipoprotein D (Apo-D) Apolipoprotein J (Apo-J) Artemin BAFF (BLyS) Betacellulin Bone Morphogenetic Protein-2 (BMP-2) Bone Morphogenetic Protein-4 (BMP-4) Bone Morphogenetic Protein-6 (BMP-6) Bone Morphogenetic Protein-7 (BMP-7) Bone Morphogenetic Protein Receptor-1A (BMPR-1A) Brain Derived Neurotrophic Factor (BDNF) BRAK (CXCL14) B-type Natriuretic Protein (BNP) C-10 (CCL6) Cardiotrophin-1 CD40 Ligand/TRAP (CD40L) Ciliary Neurotrophic Factor (CNTF) Clusterin Complement C1q Tumor Connective Tissue Growth Factor (CTGF) Cytotoxic T-Lymphocyte Associated Antigen-4/Fc Chimera Beta-Defensin-1 (BD-1) Beta-Defensin-2 (BD-2) Beta-Defensin-3 (BD-3) Endocrine Gland Vascular Endothelial Growth Factor (EG-VEGF) Endoglin Endothelial Monocyte Activating Polypeptide II (EMAPII) Eotaxin (CCL11) Epidermal Growth Factor (EGF) Epigen (EPGN) Epiregulin (EREG) Epithelial Neutrophil-Activating Protein-78 (CXCL5, ENA-78) Epstein Barr Virus Induced 3 Erythropoietin Erythropoietin alpha Fc/Chimera Exodus-2 (CCL21) Fibroblast Growth Factor-9 (FGF-9) Fibroblast Growth Factor-19 (FGF-19) Fibroblast Growth Factor-21 (FGF-21) Fibroblast Growth Factor-22 (FGF-22) Fibroblast Growth Factor-23 (FGF-23) Fibroblast Growth Factor, acidic (FGF-acidic) Fibroblast Growth Factor, basic (FGF-basic) Flt3-Ligand Follistatin (FST) Fractalkine Galectin-1 (Gal-1) Galectin-3 (Gal-3) Glial Derived Neurotrophic Factor (GDNF) Glia Maturation Factor beta (GMF-beta) Glia Maturation Factor gamma (GMF-gamma) GM-CSF/IL-3 Fusion Protein (PIXY321) Granulocyte Colony Stimulating Factor (G-CSF) Granulocyte Machrophage Colony Stimulating Factor (GM-CSF) GRO-alpha (CXCL1) GRO-beta/MIP-2 (CXCL2) GRO-gamma (CXCL3) GRO/KC (CXCL1) Growth and Differentiation Factor-5 (GDF-5) Growth Hormone (GH) Growth Hormone Antagonist (GH-A) Growth Hormone Binding Protein (GHBP) HCC-1 (CCL14) Hepatocyte Growth Factor (HGF) I-309 (CCL1) Insulin Insulin-Like Growth Factor-I (IGF-1) Insulin-Like Growth Factor-II (IGF-2) Insulin-Like Growth Factor Binding Protein-1 (IGFBP-1) Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3) Insulin-Like Growth Factor Binding Protein-5 (IGFBP-5) Insulin-Like Growth Factor Binding Protein-6 (IGFBP-6) Interferon alpha (IFN-alpha) Interferon alpha1 (IFN-alpha1) Interferon alpha1a (IFN-alpha1a) Interferon alpha1b (IFN-alpha1b) Interferon alpha2a (IFN-alpha2a) Interferon alpha2b (IFN-alpha2b) Interferon beta1a (IFN-beta1a) Interferon beta1b (IFN-beta1b) Interferon gamma (IFN-gamma) Interferon tau (IFN-tau) Interferon Regulatory Factor-1 (IRF-1) Interferon Regulatory Factor-2 (IRF-2) Interferon Regulatory Factor-3 (IRF-3) Interleukin-1 alpha (IL-1-alpha) Interleukin-1 beta (IL-1-beta) Interleukin-1 Receptor Antagonist (IL-1RA) Interleukin-2 (IL-2) Interleukin-3 (IL-3) Interleukin-4 (IL-4) Interleukin-5 (IL-5) Interleukin-6 (IL-6) Interleukin-7 (IL-7) Interleukin-8 (CXCL8) Interleukin-9 (IL-9) Interleukin-10 (IL-10) Interleukin-11 (IL-11) Interleukin-12 (IL-12) Interleukin-13 (IL-13) Interleukin-15 (IL-15) Interleukin-16 (IL-16) Interleukin-17A (IL-17A) Interleukin-18 (IL-18) Interleukin-19 (IL-19) Interleukin-20 (IL-20) Interleukin-21 (IL-21) Interleukin-22 (IL-22) Interleukin-24 (IL-24) Interleukin-27 (IL-27) Interleukin-28A (IL-28A) Interleukin-29 (IL-29) Interleukin-31 (IL-31) Interleukin-32 alpha (IL-32a) Interleukin-33 (IL-33) IP-10 (CXCL10) I-TAC (CXCL11) Keratinocyte Growth Factor (KGF) Keratinocyte Growth Factor-2 (KGF-2) Leptin Leptin Binding Domain (Leptin-BD) Leptin Triple Antagonist (Leptin-tA) Leptin Quadruple Antagonist (Leptin-qA) LeukinFeron Leukemia Inhibitory Factor (LIF) Leukocyte Function Associated Antigen-3 Fusion Protein (LFA-3) Lymphotactin Macrophage Colony Stimulating Factor (M-CSF) Macrophage Inflammatory Protein-1 alpha (CCL3) Macrophage Inflammatory Protein-1 beta (CCL4) Macrophage Inflammatory Protein-3 alpha (CCL20) Macrophage Inflammatory Protein-3 beta (CCL19) Macrophage Inflammatory Protein-4 (CCL18) Macrophage Inflammatory Protein-5 (CCL15, MIP-5) Macrophage Migration Inhibitory Factor (MIF) Melanoma Inhibitory Activity Protein (MIA) Melanoma Inhibitory Activity 2 (MIA2) Midkine MIG (CXCL9) Monocyte Chemotactic Protein-1/MCAF (CCL2, MCP-1/MCAF) Monocyte Chemotactic Protein-1 (CCL2, MCP-1) Monocyte Chemotactic Protein-2 (CCL8, MCP-2) Monocyte Chemotactic Protein-3 (CCL7, MCP-3) Monocyte Chemotactic Protein-4 (CCL13, MCP-4) Myostatin Myostatin Propeptide (GDF-8) Nerve Growth Factor beta (NGF) Neuregulin-1/Herugulin-1 (NRG1) Neuroglobin Neurotrophin-3 Neurotrophin-4 Neutrophil Activating Protein-2 (CXCL7) Noggin (NOG) Omentin Oncostatin M (OSM) Osteoclast Stimulating Factor-1 Osteopontin (Secreted Phosphoprotein-1) Osteoprotegerin (OPG) Otoraplin PEDF (Pigment Epithelium Derived Factor) Periostin (OSF-2) Pituitary Growth Hormone-20K Placenta Growth Factor-1 (PLGF-1) Placenta Growth Factor-2 (PLGF-2) Placental Growth Hormone-20K Placental Lactogen Placental-Corr Growth Hormone Platelet Derived Growth Factor-A (PDGF-A) Platelet Derived Growth Factor-AA (PDGF-AA) Platelet Derived Growth Factor-AB (PDGF-AB) Platelet Derived Growth Factor-B (PDGF-B) Platelet Derived Growth Factor-BB (PDGF-BB) Platelet Factor-4 (CXCL4, PF-4) Pleiotrophin Progranulin Prolactin Prolactin Antagonist Prolactin Receptor Prolactin Soluble Receptor Pro-Nerve Growth Factor (pro-NGF) RANK Ligand RANTES (CCL5) RELM-alpha RELM-beta RELM-gamma Resistin Retinol Binding Protein-4 (RBP-4) Sonic Hedgehog (SHH) Stem Cell Factor (SCF) Stromal Cell-Derived Factor-1 alpha (CXCL12, SDF-1a) Stromal Cell-Derived Factor-1 beta (CXCL12, SDF1b) Thrombopoietin (TPO) Thymic Stromal Lymphopoietin (TSLP) TNF-Related Apoptosis Inducing Ligand/Apo2L (TRAIL) TNFRSF17 (B-Cell Maturation Antigen) Transforming Growth Factor beta1 (TGF-b1) Transforming Growth Factor beta3 (TGF-b3) Trefoil Factor-1 (TFF1) Trefoil Factor-2 (TFF2) Trefoil Factor-3 (TFF3) Tumor Necrosis Factor alpha (TNF-a) Tumor Necrosis Factor beta (TNF-b) Tumor Necrosis Factor Receptor Fusion Protein (TNFR) Soluble Tumor Necrosis Factor Receptor Inhibitor (sTNFRI) Vascular Endothelial Growth Factor (VEGF) Vascular Endothelial Growth Factor-121 (VEGF-121) Vascular Endothelial Growth Factor-164 (VEGF-164) Vascular Endothelial Growth Factor-165 (VEGF-165) Vascular Endothelial Growth Factor-B (VEGF-B) Vascular Endothelial Growth Factor-C (VEGF-C) Vascular Endothelial Growth Factor-E (VEGF-E) Vascular Endothelial Growth Factor Related Protein (VEGF-C) Vascular Endothelial Growth Factor Inhibitor (VEGFI) Vaspin Visfatin New additions to Biomols cytokine product line in October 2009