Cytokines
Cytokines are signaling proteins in cellular communication. While hormones are secreted from specific organs to the blood, and neurotransmitters are related to neural activity, the cytokines are a more diverse class of compounds in terms of origin and purpose. They are produced by a wide variety of hematopoietic and non-hematopoietic cell types and can have autocrine, paracrine and endocrine effects, sometimes strongly dependent on the presence of other chemicals. The cytokine family consists mainly of smaller, water-soluble proteins and glycoproteins with a mass between 8 and 30 kDa.
The term cytokine is used generically for
interleukins,
chemokines,
growth factors,
neurotrophins and similar extracellular proteinaceous ligands (lymphokines, monokines,
interferons,
colony-stimulating factors, immunomodulators, immunotransmitters, etc.).
Cytokines can be isolated from natural sources or are recombinant and produced in
bacteria,
yeast or
higher eukaryotic cells. Wheras bacterially expressed ones lack post-translational modifications, the latter are glycoproteins. In many assays non-glycosylated cytokines show a similar activity as glycosylated ones, for some studies glycosylation is important.
Cytokine Product Line
Biomol,
Imgenex,
Kingfisher,
ORF Genetics,
BPS,
USBio,
Assay Designs, and
Humanzyme produce more than 1000 cytokines, all available from Biomol .
At Biomol you find this extensive range of cytokines:
| Cytokines produced in: | Cytokines of this origin: |
| |
About 400 of Biomol\'s cytokines are presented in
this pdf document (102 kB).
Cytokine and Ligand ELISA Kits
Biomol offers a selection of affordable and easy-to-use
ELISA kits for determination of concentration cytokines (and similar ligands).
Product Line Presentations
Cytokine Antibodies
Biomol offers also thousands of
antibodies for the analysis of cytokines and similar ligands.
New: Cytokine antibodies for veterinary research.
New: Antibodies raised against authentic human cytokines.
New: Bioactive cytokine rabbit monoclonal antibodies.
Authentic Human Cytokines
New: Biomol offers a range of human cytokines, which have been recombinantly produced in human cell lines. They carry authentic glycosyslation making them more stable and active:
More Info ...
HumaXPress Human Cell Line Expressed Cytokines
Neutralizing Cytokine Rabbit Monoclonal Antibodies
Epitomics has released a range of rabbit monocloanl antibodies that neutralize, block or inhibit cytokine activity. The antibodies come with IC50 data. Find here the full range, including anti-GM-CSF, anti-IL-1 beta, anti-interferon alpha, anti-IL-4, anti-IL-6, anti-IL-15, anti-RANKL, anti-TNF alpha, and anti-VEGF:
Neutralizing Cytokine Rabbit Monoclonal Antibodies
Biorisk-free Cytokines
Biomol now offers ORF Genetics\' biorisk-free cytokines. Whereas other cytokines claimed to be endotoxon-free contain about 1 EU/µg, ORF Genetics biorisk-free cytokines contain less than 0.05 EU/µg. One EU is approximately equivalent to 100 pg of
E. coli lipopolysaccharide—the amount present in around 100 bacteria. Detailed information:
Biorisk-free Cytokines.
ORF Genetics Cytokines
Angiogenin-1, human, recombinant biorisk-free cytokine
EMAP-2, human, recombinant biorisk-free cytokine
FGF acidic, human, recombinant biorisk-free cytokine
FGF basic, human, recombinant biorisk-free cytokine
Flt3-ligand, human, recombinant biorisk-free cytokine
G-CSF, human, recombinant biorisk-free cytokine
GDNF, human, recombinant biorisk-free cytokine
HB-EGF, human, recombinant biorisk-free cytokine
IFN alpha 2a, human, recombinant biorisk-free cytokine
IFN gamma, human, recombinant biorisk-free cytokine
IGF-1, human, recombinant biorisk-free cytokine
IL-1a, human, recombinant biorisk-free cytokine
IL-2, human, recombinant biorisk-free cytokine
IL-3, human, recombinant biorisk-free cytokine
IL-4, human, recombinant biorisk-free cytokine
IL-5, human, recombinant biorisk-free cytokine
IL-6, human, recombinant biorisk-free cytokine
IL-7, human, recombinant biorisk-free cytokine
IL-9, human recombinant biorisk-free cytokine
IL-16, human, recombinant biorisk-free cytokine
IL-20, human, recombinant biorisk-free cytokine
IL-22, human recombinant biorisk-free cytokine
KGF, human, recombinant biorisk-free cytokine
LIF, human, recombinant biorisk-free cytokine
LIF, mouse, recombinant biorisk-free cytokine
M-CSF, human, recombinant biorisk-free cytokine
MIP-1a, human, recombinant biorisk-free cytokine
NRG1 (HRG-beta-2), human, recombinant biorisk-free cytokine
PDGF-BB, human, recombinant biorisk-free cytokine
Prolactin, human, recombinant biorisk-free cytokine
RANKL, human, recombinant biorisk-free cytokine
SCF, human, recombinant biorisk-free cytokine
SCF, mouse, recombinant biorisk-free cytokine
Stromal cell-derived growth factor SF20
TNF alpha, human, recombinant biorisk-free cytokine
TNF-beta, human, recombinant biorisk-free cytokine
VEGF121, human, recombinant biorisk-free cytokine
VEGF165, human, recombinant biorisk-free cytokine
Kingfisher Cytokines for Veterinary Research
Kingfisher Biotech, Inc. is committed to accelerating basic veterinary research and human disease research done in animal models by developing and commercializing research reagents specific for a variety of species previously underserved in the commercial market:
Bovine (Cattle, Cow, Ox, Bull, Bos taurus)
Canine (Dog, Canis lupus familiaris)
Chicken (Cock, Hen, Gallus gallus domesticus)
Equine (Horse, Equus ferus caballus)
Feline (Cat, Felis catus)
Rabbit (Bunny, buck, doe, coney, Oryctolagus cuniculus)
Swine (Pig, Porcine, Sus domestica)
Turkey (hen, poult, tom, stag, Meleagris gallopavo)
