GSK3 beta Inhibitor TDZD-8
Looking for an inhibitor of glycogen synthase kinase-3 (GSK3) beta?TDZD-8
was found to be a key intermediate in apoptotic signaling associated with neurodegenerative diseases such as Parkinsons.
The thiadiazolidine, TDZD-8, is an inhibitor of the pro-apoptotic protein GSK-3β
(Glycogen synthase kinase 3β). GSK-3β is abundant in the nervous system, in particularly the hippocampus and plays an important role in numerous diseases including Parkinson’s disease and Alzheimer’s disease. TDZD-8 has been used to study GSK-3β in order to determine the effects of α-synuclein, a tau protein hyperphosphorylator, upon Parkinson’s disease and Alzheimer’s disease initiation. TDZD-8 also mechanism to target malignant and progenitor populations.
Biomol offer TDZD-8 from LKT Labs at a very competitive price
1. Chen G, Bower KA, Ma C et al. FASEB J. 18:1162-1164 (2004).;
2. Barry FA, Graham GJ, Fry MJ et al. FEBS letters. 553:173-178 (2003).
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