- Search results for Cay13085
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8 products were found matching "Cay13085"!
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Item number: Cay13085-10
Tenovin-1 is a small molecule activator of p53 transcriptional activity. At 10 µM, it elevates p53 expression in MCF-7 cells within two hours of treatment and longer-term exposure significantly decreases the growth of BL2 Burkitt's lymphoma and ARN8 melanoma cells. Functioning upstream of p53, tenovin-1 acts by...
Keywords: | N-[[[4-(acetylamino)phenyl]amino]thioxomethyl-4-(1,1-dimethylethyl)]-benzamide |
Application: | SIRT inhibitor |
CAS | 380315-80-0 |
MW: | 369.5 D |
From 44.00€
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Item number: Cay13308-5
DNA-dependent protein kinase (DNA-PK) binds to strand breaks produced during normal cellular processes or in response to genotoxic stresses, such as ionizing radiation, targeting substrates that facilitate DNA repair. NU 7026 is a cell-permeable, potent, specific, and ATP-competitive inhibitor of DNA-PK (IC50 = 230...
Keywords: | DNA-PK Inhibitor II, LY293646, 2-(4-morpholinyl)-4H-naphtho[1,2-b]pyran-4-one |
Application: | DNA-PK inhibitor |
CAS | 154447-35-5 |
MW: | 281.3 D |
From 109.00€
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Item number: Cay11308-5
Anisomycin is a pyrrolidine antibiotic produced by S. griseolus that inhibits protein and DNA synthesis. It activates stress-activated protein kinase, MAP kinase, and other signal transduction pathways. At 30 mg/kg, anisomycin displays immunosuppressive activity superior to that of Cyclosporine A, blocking T cell...
Keywords: | Flagecidin, NSC 76712, Wuningmeisu C, 2-[(4-methoxyphenyl)methyl]-3-acetate-(2R,3S,4S)-3,4-pyrrolidinediol |
Application: | Protein and DNA synthesis inhibitor |
CAS | 22862-76-6 |
MW: | 265.3 D |
From 46.00€
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Item number: Cay13089-5
Radicicol is an inhibitor of heat shock protein 90 (Hsp90, IC50 = erb82, and mutant p53. Radicicol also binds to and inhibits DNA topoisomerase type II proteins and GRP94 through an ATPase domain common to Hsp90.Formal Name:...
Keywords: | KF58332, KF9-A, Monorden, NSC 294404,... |
Application: | Hsp90 inhibitor |
CAS | 12772-57-5 |
MW: | 364.7 D |
From 43.00€
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Item number: Cay13086-5
The tumor suppressor function of p53 hinges on its ability to function as a transcription factor. Tenovin-6 is an analog of tenovin-1, a small molecule activator of p53 transcriptional activity. At 10 µM, this compound is slightly more effective than tenovin-1 at elevating p53 activity in MCF-7 cells and reduces...
Keywords: | N-[[[4-[[5-(dimethylamino)-1-oxopentyl]amino]phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-benzamide |
Application: | SIRT inhibitor |
CAS | 1011301-29-3 |
MW: | 491.1 D |
From 65.00€
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Item number: Cay13084-5
STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM). It significantly reduces the growth rate of tumors formed from VHL-deficient cells in mice. STF-62247...
Keywords: | N-(3-methylphenyl)-4-(4-pyridinyl)-2-thiazolamine |
Application: | Autophagy inducer |
CAS | 315702-99-9 |
MW: | 267.3 D |
From 81.00€
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Item number: Cay13083-5
The rapid, selective, and sensitive sensing of thiols is important in diverse areas of research. This Thiofluor 623 responds upon exposure to thiols with an increase in fluorescence intensity of up to 120-fold. The response is selective for thiols and occurs in aqueous media. In the absence of thiols, the probe is...
Keywords: | Fluorescent Thiol Probe,... |
Application: | Fluorescent probe |
CAS | 1004324-99-5 |
MW: | 678.7 D |
From 226.00€
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COVID-19 Research
Item number: Cay13082-5
Angiotensin-converting enzyme 2 (ACE2) is an enzyme that is cardioprotective and renoprotective. Resorcinolnaphthalein increases the activity of ACE2 in vitro (EC50 = 19.5 µM). Activation of ACE2 in rats produces a decrease in blood pressure and improvement in cardiac function. In spontaneously hypertensive rats it...
Keywords: | NSC 354317, 3',6'-dihydroxy-spiro[1H,3H-naphtho[1,8-cd]pyran-1,9'-[9H]xanthen-3-one |
Application: | ACE2 activation |
CAS | 41307-63-5 |
MW: | 382.4 D |
From 28.00€
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