Anti-E6AP

Anti-E6AP
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A300-352A-T 10 µl (10 µg) -

2 - 8 business days*

164.00€
A300-352A 100 µl (100 µg) -

2 - 8 business days*

588.00€
 
Protein function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2... more
Product information "Anti-E6AP"
Protein function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation (PubMed:24728990). Acts as transcriptional coactivator of progesterone receptor PGR upon progesterone hormone activation (PubMed:16772533). Synergizes with WBP2 in enhancing PGR activity (PubMed:16772533). [The UniProt Consortium]
Keywords: Anti-E6AP, Anti-UBE3A, EC=2.3.2.26, Anti-Ubiquitin-protein ligase E3A, Anti-E6AP ubiquitin-protein ligase, Anti-Renal carcinoma antigen NY-REN-54, Anti-HECT-type ubiquitin transferase E3A, Anti-Oncogenic protein-associated protein E6-AP
Supplier: Bethyl Laboratories
Supplier-Nr: A300-352A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: X. laevis, X. tropicalis, chicken, turkey, rabbit, guinea pig_10141, pig, panda, orangutan, rhesus monkey, gorilla, chimpanzee, medaka fish, percoidei, cichlidae, nile tilapia, japanese sea perch, barramundi, siniperca kneri)
Immunogen: synthetic peptide. The epitope recognized by A300-352A maps to a region between residue 400 and 450 of human Ubiquitin Protein Ligase E3A using the numbering given in entry NP_000453.2 (GeneID 7337).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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