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Specificities of Lectins

Lectins bind carbohydrates.
Here you find some Lectin specificities:

Mannose binding lectins:

  • Concanavalin A (Con A, Canavalia ensiformis): branched α-mannosidic structures; high-mannose type, hybrid type and biantennary complex type N-Glycans

  • Lentil lectin (LCH, Lens culinaris): Fucosylated core region of bi- and triantennary complex type N-Glycans

  • Snowdrop lectin (GNA, Galanthus nivalis): α1-3 and α1-6 linked high mannose structures

Galactose / N-acetylgalactosamine binding lectins:

  • Ricinus communis Agglutinin, RCA120 (RCA, Ricinus communis): Galβ1-4GlcNAcβ1-R

  • Peanut Agglutinin (PNA, Arachis hypogaea): Galβ1-3GalNAcα1-Ser/Thr (T-Antigen)

  • Jacalin (AIL, Artocarpus integrifolia): (Sia)Galβ1-3GalNAcα1-Ser/Thr

  • Hairy vetch lectin (VVL, Vicia villosa): GalNAcalpha-Ser/Thr (Tn-Antigen)

Sialic acid / N-acetylglucosamine binding lectins:

  • Wheat Germ agglutinin (WGA, Triticum vulgaris): GlcNAcβ1-4GlcNAcβ1-4GlcNAc, Neu5Ac (sialic acid)

  • Elderberry lectin (SNA, Sambucus nigra): Neu5Acα2-6Gal(NAc)-R

  • Maackia amurensis lectin (MAL, Maackia amurensis): Neu5Ac/Gcα2-3Galβ1-4GlcNAcβ1-R

Fucose binding lectins:

This list does not claim to be complete.



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