| Hsp70 Family |
| Name | Synonyms | Entrez Gene ID | Swiss Prot ID | Function / Structure | Related Products |
| APG-1 | HspA4L, Osp94 | 22824 | O95757 | Hsp110 subfamily | Antibodies (IMX-30577, H1830-34A.100) |
| APG-2 | HspA4, Irp94, Hsp70RY | 3308 | P34932 | Hsp110 subfamily; phosphorylated upon DNA damage, probably by ATM or ATR | APG-2 Antibodies |
| BIP / Grp78 | HspA5, Hsp70-5 | 3309 | P11021 | Constitutively expressed ER form of Hsp70, also referred to as immunoglobulin heavy chain binding protein | BIP / Grp78 Antibodies , Proteins (SPR-107, SPR-119) |
| Grp75 / Mortalin | MtHsp70, HspA9, Hsp70-9, MOT, Mot-2 | 3313 | P38646 | Mitochondrial form of Hsp70; constitutively expressed; cooperates with Hsp60 to fold preproteins following transit across mitochondrial membrane | Grp75 / Mortalin Antibodies (SMC-133), Protein (H1830-91C) |
| Hsc70 | HspA8, Hsp70-8, Hsp73, Hsc71 | 3312 | P11142 | Constitutively expressed in most tissues; essential housekeeping gene; two isoforms due to alternative splicing | ELISA (SKT-106) Hsc70 Antibodies (SMC-151, SPC-102, 200-301-A28, IMG-30125), Protein (SPR-106) |
| Hsp70-4 | Hsp70L1 HspA14 | 51182 | Q0VDF9 | Hsp70-like protein 1; cloned from human dendritic cells | Hsp70-4 Antibodies |
| Hsp70B | HspA7 | 3311 | P48741 | Tightly linked to Hsp70B locus | Antibody (H1834-40M) |
| Hsp70B' | HspA6, Hsp70-6 | 3310 | P17066 | Strictly stress-inducible; in unstressed conditions it is expressed only in certain blood cells (dendritic cells, monocytes and NK cells) |
Hsp70B' Antibodies, Protein (H1831-05) |
| Hsp70-Hom | HspA1L, Hum70t, Hsp70-1t | 3305 | P34931 | Constitutive, testis-specific expression; locus adjacent to Hsp72 and Hsp70-2 | HspA1L Antibodies |
| Hsp72 | HspA1A, Hsp70-1a, Hsp70-1 | 3303 | P08107 | Stress inducible; highly expressed in various cancers; correlated with increased proliferation, metastasis and poor outcome in breast cancer | ELISA (SKT-105), Hsp72 Antibodies (SMC-100, 200-301-A27), Proteins (SPR-103, SPR-108, SPR-115, SPR-117) |
| Hsp72 | HspA1B, Hsp70-1b, Hsp70-1 | 3304 | P08107 | Stress inducible; identical in protein sequence to HspA1A above, but transcribed from an adjacent locus | ELISA (SKT-105), Hsp72 Antibodies (
SMC-100, 200-301-A27), Proteins (SPR-103, SPR-108, SPR-115, SPR-117) |
| Hsp110 | Hsp105, HspH1 | 10808 | Q92598 | Hsp110 subfamily; acts as nucleotide exchange factor for Hsp70 | HspH1 Antibodies (SPC-195) |
| HspA2 | Hsp70-2 | 3306 | P54652 | Constitutively expressed at high levels in brain and testis; role in spermatogenesis; upregulated in a subset of breast cancers and has growth and survival promoting effects in cancer cells | Antibody (H7656-25A) |
| HYOU1 | Hypoxia upregulated 1, Grp170, ORP 150 | 10525 | Q9Y4L1 | Induced by hypoxia, found in the ER, upregulated in tumors; protein with alternative translation start site found in the cytoplasm | HYOU1 Antibodies |
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| Hsp70/Hsp40 Associated Co-chaperones & Others |
| Name | Synonyms | Entrez Gene ID | Swiss Prot ID | Function / Structure | Related Products |
| Bag-1 | HAP | 573 | Q99933 | BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release; two splice variants | Bag-1 Antibodies (IMG-5672, IMG-5673) |
| Bag-2 | NA | 9532 | O95816 | Associates with CHIP and inhibits / regulates its activity by inhibiting the interaction between CHIP and its cognate ubiquitin-conjugating enzyme, UbcH5a; phosphorylated at Ser20 by MAPKAPK-2 | Bag-2 Antibodies (IMG-3842, IMG-5674) |
| Bag-3 | BIS | 9531 | O95817 | Binds ATPase domain of Hsp70/Hsc70, inhibits chaperone activity | Bag-3 Antibodies (IMG-5675, IMG-5676) |
| Bag-4 | SODD | 9530 | O95429 | Inhibits Hsp70/Hsc70; prevents constitutive TNFRSF1A signaling; cytosolic | SODD Antibodies (IMG-5677) |
| Bag-5 | NA | 9529 | Q9UL15 | Negative regulator of Hsp70; two alternative splice forms | Bag-5 Antibodies (IMG-5678) |
| BAP | SIL1 | 64374 | Q9H173 | ER localized protein that is associated with BiP/Grp94 and serves as a nucleotide exchange factor for it; mutations associated with Marinesco-Sjogren syndrome; two splice variants that encode the same protein | SIL1 Antibodies (IMG-3557) |
| CHIP | STUB1, UBOX1, HSPABP2 | 10273 | Q9UNE7 | Carboxyl terminus of Hsp70 Interacting Protein; an Hsp70-associated E3 ubiquitin ligase that targets chaperone substrates to the proteasome; inhibited by Hip and BAG-2; interacts with HSF1 upon heat shock; substrates include AR, Tau, Smad1/4, nNOS and Cu/Zn-SOD | STUB1 Antibodies (IMG-3137, A301-572A, A301-573A, IHC-00345), Protein (C4125-03D) |
| Hip | HspBP1 | 23640 | Q9NZL4 | Nucleotide exchange factor for Hsp70; inhibits the ubiquitin ligase activity of CHIP; an anti-apoptotic protein and substrate of Granzyme B | HspBP1 Antibodies (H1834-41A, H1834-41D), Protein (H7653) |
| Hop | STIP1, STI1 | 10963 | P31948 | Hsp70/Hsp90-organizing protein; Stress induced Phosphoprotein 1; binds EEVD motifs at the C-termini of Hsp70 and Hsp90; also binds Cdc37; normally found in the cytoplasm, but also seen in the nucleus depending on cell cycle/CDK activity | STIP1 Antibodies, Protein (SRP-1510, SPR-302) |
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| Hsp40/DnaJ Family |
| Name | Synonyms | Entrez Gene ID | Swiss Prot ID | Function / Structure | Related Products |
| CSP | Cysteine String Protein, DnaJC5 | 80331 | Q9H3Z4 | Secretory vesicle protein involved in regulated exocytosis; plays a role in CFTR biogenesis and trafficking; interacts with the inactive GDP-bound form of Galpha(s) and promotes GDP/GTP exchange; guanine nucleotide exchange activity regulated by Hsc70 and SGT | Csp (rat) Antibody (C9020-01) |
| CSP-beta | DnaJC5B | 85479 | Q9UF47 | Testis specific expression; palmitoylated | Primers VHPS-2673 |
| CSP-gamma | DnaJC5G | 285126 | Q8N7S2 | Testis specific expression; palmitoylated | |
| DnaJA4 | NA | 55466 | Q8WW22 | Hsp40 homolog | Antibody (D4015-07Y) |
| DnaJA5 | DjC21, DNAJC21 | 134218 | Q5F1R6 | Hsp40 homolog; three splice variants; expressed in brain, placenta, kidney, and pancreas | Antibodies (A301-884A, A301-885A, A310-668A) |
| DnaJB12 | NA | 54788 | Q9NXW2 | Possibly membrane associated | Primers VHPS-2665 |
| DnaJB13 | TSARG6 | 374407 | P59910 | Expressed specifically in adult testis, implicated in apoptosis in spermatogenic cells | |
| DnaJB14 | NA | 79982 | Q8TBM8 | Possibly membrane associated; two splice variants | |
| DnaJB8 | NA | 165721 | Q8NHS0 | Hsp40 homolog | |
| DnaJC11 | FLJ10737 | 55735 | Q9NVH1 | Candidate tumor suppressor gene of neuroblastoma; found in mitochondria | Primers VHPS-2670 |
| DnaJC16 | NA | 23341 | Q9Y2G8 | Possibly type IV single-pass membrane protein; two splice variant | |
| DnaJC17 | NA | 55192 | Q9NVM6 | Hsp40 homolog; contains RNA recognition motif | Primers VHPS-2671 |
| DnaJC18 | NA | 202052 | Q9H819 | Possibly single-pass membrane protein | |
| DnaJC19 | TIM14 | 131118 | Q96DA6 | Mitochondrial protein, similar in sequence to yeast Tim14 which is involved in mitochondrial protein import; mutated in DCMA syndrome (dilated cardiomyopathy with ataxia) | Antibodies (D4015-08V, D4015-08V1) |
| DnaJC4 | HSPF2; MCG18 | 3338 | Q9NNZ3 | Possibly single-pass membrane protein | Primers VHPS-2672 |
| DnaJC6 | DJC6 | 9829 | O75061 | Involved in uncoating of clathrin coated vesicles; interacts with Hsc70; three splice variants | Antibody (D4015-08G) |
| DnaJC7 | TPR2; TTC2 | 7266 | Q99615 | Interacts with GAP domain of NF1 | Antibody (D4015-08J1) |
| DnaJC8 | SPF31 | 22826 | O75937 | Splicing protein spf31 | Antibody (A301-839A) |
| DRIP78 | HDJ3; DnaJC14 | 85406 | Q6Y2X3 | May regulate trafficking of GPCRs including Angiotensin II and Dopamine Receptor; may play a role as a chaperone in the assembly of G-beta/gamma subunits | |
| ERdj3 | DnaJB11, ERj3, HEDJ; ABBP-2 | 51726 | Q9UBS4 | ER localized, expression induced by ER stress; stimulates BiP ATPase activity | Antibody (ABD-8C15492), Protein (D4015-12) |
| ERdj5 | JPDI; DnaJC10 | 54431 | Q8IXB1 | ER localized, expression induced by ER stress (UPR); also a member of the Protein Disulfide Isomerase family | Antibody (SPC-114) |
| Hdj2 | DnaJA1, DJ2; DJA1; HSDJ; HSJ2; Hsp40-4 | 3301 | P31689 | Farnesylated; interacts with Hsc70; two splice forms, one nuclear, one expressed throughout the cell | Primers (VHPS-2661) |
| HdjC9 | JDD1; DnaJC9; DjC9 | 23234 | Q8WXX5 | Hsp40 homolog | Antibody (A301-840A) |
| Hlj1 | DnaJB4, DjB4; DnaJW | 11080 | Q9UDY4 | Identified in human liver | Antibody (ABD-8C12333) |
| HSC3 | DnaJB7 | 150353 | Q7Z6W7 | ER localized, expression induced by ER stress (UPR); also a member of the Protein Disulfide Isomerase family | |
| Hsc40 | DnaJB5 | 25822 | O75953 | Constitutive Hsp40 isoform | Antibody (D4015-08A10) |
| HscB | DnaJC20, Jac1, Hsc20 | 150274 | Q8IWL3 | Homolog of E. coli HscB, which along with the E. coli Hsp70 homolog HscA forms part of a specialized system for synthesizing iron-sulfur proteins; candidate gene in hereditary ataxia syndromes | |
| Hsj1 | DnaJB2, HSPF3 | 3300 | P25686 | Neuronal tissue-specific; two isoforms (Hsj1a and Hsj1b) | Antibody (D4015-08A1) |
| Hsp40/Hdj1 | DnaJB1, HSPF1 | 3337 | P25685 | Enhances ATPase activity of Hsp70 family members |
DnaJB1 Antibodies (SPC-100, SMC-145), Protein (BPS-50285) |
| Htj1/ERdj1 | DNAJC1, DNAJL1, MTJ1 | 64215 | Q96KC8 | Enriched in microsomes and nucleus; stimulates BiP ATPase activity; involved in transport of BiP to the cell surface | Primers (VHPS-2669) |
| JDP1 | DnaJC12 | 56521 | Q9UKB3 | An estrogen target gene, highly expressed in ER positive breast cancer; two isoforms; conserved down to Drosophila | |
| MCJ | HSD18, DNAJD1, DNAJC15 | 29103 | Q9Y5T4 | Methylation controlled J protein (MCJ) is a type II transmembrane cochaperone localized in the Golgi network and present only in vertebrates | Primers (VHPS-2676) |
| Mdg1/ERdj4 | DnaJB9 | 4189 | Q9UBS3 | ER localized, expression induced by UPR; expression associated with low metastatic potential; stimulates BiP ATPase activity | Antibody (IMX-3732) |
| MPP11 | MIDA1, DnaJC2, Zrf1, Zrf2 | 22791 | P54103 | Localized to nucleus; ubiquitously expressed | |
| Mrj | DnaJB6, Hsj2; Msj1 | 10049 | O75190 | Enriched in the CNS; two isoforms as a result of alternative splicing; one nuclear, one expressed throughout the cell; binds and regulates NFAT | Antibodies (D4015-08B2) |
| P58(IPK) | DnaJC3, PRKRI; | 5611 | Q13217 | Binds and inactivates PKR; induced by ER stress, binds and inactivates PERK | Antibodies (D4015-08F1) |
| Rdj2 | DnaJA2, DJA2, CPR3, HIRIP4, Dnj3, Dj3 | 10294 | O60884 | Hsc70 co-chaperone; possibly membrane associated and farnesylated | Antibody (D4015-07T) |
| RME-8 | DnaJC13 | 23317 | O75165 | Functions in endosomal trafficking; human homolog of Receptor mediated endocytosis 8 (RME8) in C. elegans; widely expressed, binds Hsc70 | |
| Tid1 | hTid-1, DnaJA3 | 9093 | Q96EY1 | Mitochondrial; modulates apoptotic signal transduction, cytochrome c release, and caspase 3 activation; two splice variants | Antibody (T5498-55) |
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| Hsp60/Hsp10 Family |
| Name | Synonyms | Entrez Gene ID | Swiss Prot ID | Function / Structure | Related Products |
| CCT2 | chaperonin containing TCP1 subunit 2 (beta), TCP1-beta, CCTB, CCT-beta; | 10576 | P78371 | Component of hetero oligomeric TRiC complex | CCT2 Antibodies |
| CCT3 | chaperonin containing TCP1 subunit 3 (gamma), CCTG, CCT-gamma, TRIC5, TCP1-gamma | 7203 | P49368 | Component of hetero oligomeric TRiC complex; three alternative splice forms | CCT3 Antibodies (IMG-30887, A303-458A, A303-459A) |
| CCT4 | chaperonin containing TCP1 subunit 4 (delta), SRB, CCTd | 10575 | P50991 | Component of hetero oligomeric TRiC complex | Antibodies (T2035-25) |
| CCT5 | chaperonin containing TCP1 subunit 5 (epsilon), CCTE, CCT-epsilon, TCP1-epsilon | 22948 | P48643 | Component of hetero oligomeric TRiC complex; mutation associated with autosomal recessive mutilating sensory neuropathy with spastic paraplegia; expression up-regulated in p53-mutated tumors | CCT5 Antibodies |
| CCT6A | chaperonin containing TCP1 subunit 6A (zeta 1), CCT6, CCTz, HTR3, TCPZ, TCP20, MoDP-2, TTCP20, CCT-zeta, CCT-zeta1, TCP1-zeta | 908 | P40227 | Component of hetero oligomeric TRiC complex; ionizing radiation results in enhanced expression in radioresistant cancer cells compared to radiosensitive cells; two alternative splice forms | CCT6A Antibodies |
| CCT6B | chaperonin containing TCP1 subunit 6B (zeta 2), CCT-zeta2; TCP1-zeta2 | 10693 | Q92526 | Component of hetero oligomeric TRiC complex; tesis specific expression | Primers (VHPS-1658) |
| CCT7 | chaperonin containing TCP1 subunit 7 (eta), HIV-1 Nef interacting protein ( Nip7-1), TCP1-eta, Ccth, CCT-Eta | 10574 | Q99832 | Component of hetero oligomeric TRiC complex; two alternative splice forms | Antibody (T2035-35) |
| CCT8 | C21orf112, CCT-theta, TCP-1-theta, T-complex protein 1 subunit theta, Renal carcinoma antigen NY-REN-15 | 10694 | P50990 | Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. | Antibodies (A303-446A, A303-447A, A303-448A, A303-449A) |
| Hsp10 | CPN10, GroES, HSPE1 | 3336 | P61604 | Closely linked to the Hsp60 gene (HspD1); forms chaperonin cap structure | Hsp10 Antibodies (SPC-193), Protein (SPR-310) |
| Hsp60 | HspD1, CPN60, GroEL, HSP65, SPG13, HuCHA60 | 3329 | P10809 | Mitochondrial protein essential for folding and assembly of newly imported proteins; also a signaling molecule in the innate immune system; mutations associated with autosomal recessive spastic paraplegia | ELISA (SKT-110-96), HspD1 Antibodies (SMC-110, SMC-111), Protein (SPR-104) |
| TCP1 | CCT1, CCT-alpha, TCP1-alpha | 6950 | P17987 | Member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC), consisting of two identical stacked rings, each containing eight different proteins; the complex folds various proteins, including actin and tubulin, in an ATP dependent manner; two alternative splice forms;unlike Hsp60, no known associated Hsp10/GroES cofactor | TCP1 Antibodies (A303-443A, A303-444A, A303-445A) |
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| Hsp90 Family |
| Name | Synonyms | Entrez Gene ID | Swiss Prot ID | Function / Structure | Related Products |
| Grp94 | Hsp90B1, Gp96 | 7184 | P14625 | ER form; glucose regulated and induced by glucose starvation; participates in protein folding and assembly, protein secretion, protecting cells from apoptosis, and mediating immunogenicity; C-terminal sequence KDEL mediates
retention in the ER; two splice variants | Grp94 Antibodies (SMC-105), Protein (G3057-44C) |
| Hsp90 alpha | Hsp90AA1, Hsp86, Hsp89, HSP90A, HSPC1, HSPCA | 3320 | P07900 | Cytosolic form, induced by elevated temperature; ATPase activity; three splice variants | Assay Kit (BPS-50293, BPS-50298) ELISA (SKT-107), HSP90A Antibodies (SMC-147, 600-401-929), Protein (SPR-101) |
| Hsp90 alpha | Hsp90AA2 | 3324 | Q14568 | Cytosolic form, induced by elevated temperature | |
| Hsp90 beta | Hsp90AB1 | 3326 | P08238 | Cytosolic form, constitutively expressed; ATPase activity; three splice variants | Assay Kit (BPS-50294, BPS-50299), Hsp90 beta Antibodies (SMC-136, SPC-177) Protein (SPR-102) |
| TRAP1 | Hsp75 | 10131 | Q12931 | Mitochondrial form; has ATPase activity that is inhibited by both geldanamycin and radicicol; highly conserved through evolution; phosphorylation by PINK1 prevents oxidative-stress-induced apoptosis; four splice variants | Protein (Cay11105), Antibody (SMC-193D) |
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| Hsp90 Associated Co-chaperones & Others |
| Name | Synonyms | Entrez Gene ID | Swiss Prot ID | Function / Structure | Related Products |
| Aha1 | Activator of Hsp90 ATPase homolog 1, Ahsa1, p38 | 10598 | O95433 | Stimulates the inherent ATPase activity of Hsp90 | AHA1 Antibodies (SMC-172, SMC-173, SPC-183), Proteins (SPR-300, SPR-309) |
| Cdc37 | NA | 11140 | Q16543 | A chaperone that binds Hsp90 and is required for the activity of numerous protein kinases | Cdc37 Antibodies (SPC-?142D, A302-488A, A302-489A), Protein (C2562-05C) |
| Hop | STIP1, STI1 | 10963 | P31948 | Golgi; Hsp70/Hsp90 organizing protein; Stress induced Phosphoprotein 1; binds EEVD motifs at the C-termini of Hsp70 and Hsp90; also binds Cdc37; normally found in the cytoplasm, but also seen in the nucleus depending on cell cycle/CDK activity | HOP Antibodies), Protein (SPR-302) |
| p23 | TEBP, PGE Synthase 3 | 10728 | Q15185 | Binds to telomerase and progesterone receptor; also functions as a cytosolic prostaglandin E2 synthase; phosphorylated at Ser113, 118, 148 and 151 and acetylated at Lys33 | PGE Synthase 3 Antibodies (SMC-156), Protein (SPR-303) |
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| Small Hsp Family (sHsps) |
| Name | Synonyms | Entrez Gene ID | Swiss Prot ID | Function / Structure | Related Products |
| Crystallin, alpha A | CRYAA, CRYA1, HSPB4 | 1409 | P02489 | Expression restricted to the lens | Antibody (SMC-142, C7944-72C.100) |
| Crystallin, alpha B | CRYAB, CRYA2, HSPB5 | 1410 | P02511 | Broad tissue expression; elevated expression in many neurological diseases; a missense mutation associated with a desmin-related myopathy | ELISA Kit (SKT-123), CRYAB Antibodies (SMC-159, SMC-165) |
| Heat shock 22kDa protein 8 | H11, E2IG1, HSP22, HSPB8 | 26353 | Q9UJY1 | Charcot-Marie-Tooth disease type 2L; Hereditary motor neuropathy type II | HSP22 Antibodies (IMG-3535, SPC-181, SMC-187) |
| heat shock 27kDa protein 1 | Hsp27, Hsp25, HSPB1 | 3315 | P04792 | Charcot Marie Tooth disease, axonal, type 2F; distal hereditary motor neuropathy | ELISA Kit (SKT-109), HSPB1 Antibodies (SMC-161, 200-301-243), Proteins (SPR-118) |
| heat shock 27kDa protein 2 | HSPB2, MKBP | 3316 | Q16082 | Associates with myotonic dystrophy protein kinase (DMPK) | HSPB2 Antibodies (SPC-194) |
| heat shock 27kDa protein 3 | HSPB3, HSPL27 | 8988 | Q12988 | Inhibitor of actiin polymerization | |
| heat shock 27kDa protein family, member 7 (cardiovascular) | cvHSP, HspB7 | 27129 | Q9UBY9 | Bovine ?H-crystallin | Protein (H1834-80) |
| heat shock protein, alpha crystallin related, B6 | HSPB6, Hsp20 | 126393 | O14558 | Structural component of eye lens | Hsp20 Antibodies (H1830-48D) |
| heat shock protein, alpha crystallin related, B9 | HSPB9, CT51 | 94086 | Q9BQS6 | Testis specific | Primers (VHPS-4335) |
| outer dense fiber of sperm tails 1 | HSPB10, ODFP, SODF, ODF1 | 4956 | Q14990 | Component of outer dense fibers of spermatozoa; testis specific expression | Primers (VHPS-6441) |
| Beta/gamma Crystallin family |
| Crystallin, beta A1 | CRYBA1 | 1411 | P05813 | Mutation causes the autosomal dominant disease zonular cataract with sutural opacities; member of the acidic group of beta crystallins; beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta crystallins | Primers (VHPS-2238) |
| Crystallin, beta A2 | CRYBA2 | 1412 | P53672 | Member of the acidic group of beta crystallins | Primers (VHPS-2239) |
| Crystallin, beta A4 | CRYBA4 | 1413 | P53673 | Member of the acidic group of beta crystallins; part of a gene cluster with beta B1, beta B2, and beta B3; mutations linked to cataractogenesis and microphthalmia | Primers (VHPS-2240) |
| Crystallin, beta B1 | CRYBB1 | 1414 | P53674 | Member of the basic group of beta crystallins | Primers (VHPS-2241) |
| Crystallin, beta B2 | CRYBB2 | 1415 | P43320 | Member of the basic group of beta crystallins; mutation found to cause type 2 cerulean cataracts | Primers (VHPS-2242) |
| Crystallin, beta B3 | CRYBB3 | 1417 | P26998 | Member of the basic group of beta crystallins | Primers (VHPS-2243) |
| Crystallin, gamma A | CRYGA, CRYG1, CRYG5 | 1418 | P11844 | Part of a gene cluster with gamma B, C and D, and the pseudogenes gamma-E, F and G; gamma crystallins are monomeric proteins and have been implicated in cataract formation | |
| Crystallin, gamma B | CRYGB, CRYG2 | 1419 | P07316 | Part of a gene cluster with gamma A, C and D, and the pseudogenes gamma-E, F and G; gamma crystallins are monomeric proteins and have been implicated in cataract formation | Primers (VHPS-2244) |
| Crystallin, gamma C | CRYGC, CRYG3, CCL | 1420 | P07315 | Part of a gene cluster with gamma A, B, and D, and the pseudogenes gamma-E, F and G; gamma crystallins are monomeric proteins and have been implicated in cataract formation | Primers (VHPS-2245) |
| Crystallin, gamma D | CRYGD, CRYG4, CCP, PCC, CACA, CCA3 | 1421 | P07320 | Part of a gene cluster with gamma A, B, and C, and the pseudogenes gamma-E, F and G; gamma crystallins are monomeric proteins and have been implicated in cataract formation | Antibody (C7944-88), Primers (VHPS-2246) |
| Crystallin, gamma N | CRYGN | 155051 | Q496G6 | beta-gamma hybrid crystallin; expressed in retina and lens nuclear fibers in rodents | |
| Crystallin, gamma S | CRYGS, CRYG8 | 1427 | P22914 | The most significant gamma-crystallin in adult eye lens tissue | |
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| Other Hsps and Chaperones |
| Name | Synonyms | Entrez Gene ID | Swiss Prot ID | Function / Structure | Related Products |
| Calnexin | CNX, P90 | 821 | P27824 | Calcium binding ER protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly; it may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation | Calnexin Antibodies (SPC-108, SPC-127, SPC-182) |
| Calreticulin | CRTC, ERp60, grp60 | 811 | P27797 | Calcium binding ER protein; also found in the nucleus; can bind and inhibit nuclear hormone receptors | Calreticulin Antibodies (SPC-122 ), Calreticulin Protein |
| CHIP | STUB1, UBOX1, HspABP2 | 10273 | Q9UNE7 | E3 ubiquitin ligase; co-chaperone that associates with Hsp70 and Hsp90 | CHIP Antibodies (IMG-3137, A301-572A), CHIP Protein |
| HO-1 | heme oxygenase (decyclizing) 1, HMOX1, Hsp32 | 3162 | P09601 | Highly inducible by heavy metals, endotoxin, oxidizing agents, UVA; cleaves heme ring at the alpha methene bridge to form biliverdin | HO-1 ELISA (
SKT-?111), HO-1 Antibodies (SMC-131), HO-1 Protein (H1847-68E) |
| HO-2 | heme oxygenase (decyclizing) 2, HMOX2 | 3163 | P30519 | Non-inducible; cleaves heme ring at the alpha methene bridge to form biliverdin | Antibodies (H1847-69J), Protein (H1847-81A) |
| HSF-1 | HSTF1 | 3297 | Q00613 | Regulates the program of heat shock gene expression. Expression repressed by Hsp90; positively and negatively regulated by phosphorylation; modified by SUMO-1 and SUMO-2 in a stress-inducible manner | HSF-1 Antibodies (SMC-118), Protein (H1830-44A
) |
| HSF-2 | HSTF2 | 3298 | Q03933 | Regulates the program of heat shock gene expression | HSF-2 Antibodies (ABD-8C10871) |
| Hsp47 | SerpinH1, Colligin, Gp46 | 871 | P50454 | ER-localized member of the serpin family of serine protease inhibitors; expression induced by heat shock; binds collagen and thought to be a chaperone involved in the maturation of collagen; autoantibodies found in patients with rheumatoid arthritis | Hsp47 Antibodies, Protein (H1834-20E) |
| KDELR1 | ERD2 | 10945 | P24390 | Family of seven transmembrane receptors that mediate the retention of proteins with the sequence lys-asp-glu-leu (KDEL), such as Grp78 and Grp94, in the lumen of the ER | Antibody (SMC-129) |
| KDELR2 | ERD2.2 | 11014 | P33947 | Two alternative splice forms | KDELR2 Antibodies |
| KDELR3 | ERD2L3 | 11015 | O43731 | Two alternative splice forms | Antibody (ABD-8C15674) |
| UGGT | UDP-glucose : glycoprotein glucosyl transferase, HUGT1, UGCGL1, GT, UGT1, UGTR | 56886 | Q9NYU2 | Recognizes glycoproteins with minor folding defects; reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum; reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation | UGGT (rat) Antibody (U1275) |
| Protein Disulfide Isomerase (PDI) Family |
| ERdj5 | JPDI; DnaJC10 | 54431 | Q8IXB1 | Expression induced by ER stress; also a member of the DnaJ family | |
| ERp18 | TXNDC12, AGR1, ERp19 | 51060 | O95881 | Member of the thioredoxin superfamily; expressed in ER lumen | |
| ERp27 | NA | 121506 | Q96DN0 | Interacts with PDIA3; does not contain a CXXC active site motif indicating that it is a catalytically redox-inactive member of the protein disulfide isomerase family | |
| ERp29 | ERp28, ERp31, PDI-DB | 10961 | P30040 | Similar in sequence to the PDI family, but lacks a thioredoxin motif, suggesting it does not function as a disulfide isomerase; the protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER; two alternative splice forms | ERp29 Antibodies (IMG-30767, E2291-71) |
| ERp44 | TXNDC4 | 23071 | Q9BS26 | Induced by ER stress | ERp44 Antibodies (IMG-30517) |
| ERp46 | TXNDC5 | 81567 | Q8NBS9 | Highly expressed in endothelial cells, where it is induced by and protects against hypoxia; contains 3 thioredoxin domains; two isoforms | Antibody (IMG-3363) |
| ERp57 | Grp58, PDIA3 | 2923 | P30101 | ER protein with protein disulfide isomerase activity that interacts with the lectin chaperones calreticulin and calnexin to modulate the folding of newly synthesized glycoproteins | ERp57 Antibodies (SMC-168), Protein (E2291-75G-P) |
| ERp72 | PDIA4, ERp70 | 9601 | P13667 | Catalyzes rearrangement of disulfide bonds | Antibody (E2291-77C) |
| P5 | PDIA6, ERP5, TXNDC7 | 10130 | Q15084 | Can also function on the cell surface | Antibody (P3122-36) |
| PDI | PDIA1, P4HB | 5034 | P07237 | Catalyzes S-S bond formation, breakage, and rearrangement in nascent (ER lumen) and cell surface proteins | P4HB Antibodies), Protein (P3122) |
| PDILT | | 204474 | Q8IVQ5 | Testis-specific expression | |
| PDIP | PDIA2 | 64714 | Q13087 | Catalyzes S-S bond rearrangement; expressed in ER lumen; high expression in pancreas | Antibody (IMG-30290) |
| PDIR | PDIA5 | 10954 | Q14554 | Contains 3 thioredoxin domains | Antibody (P3122-07) |
| TMX | TXNDC1 | 81542 | Q9H3N1 | Contains one thioredoxin domain and a putative transmembrane domain | TMX Antibodies (IMG-3324) |
| TMX2 | TXNDC14 | 51075 | Q561W0 (TrEMBL ID) | Contains one thioredoxin domain and a putative transmembrane domain | |
| TMX3 | TXNDC10 | 54495 | Q96JJ7 | Contains one thioredoxin domain and a putative transmembrane domain | |
| TMX4 | TXNDC13 | 56255 | Q9H1E5 | Contains one thioredoxin domain and a putative transmembrane domain | Primers (VHPS-2613) |
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